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手术治疗胃肠道间质瘤的疗效观察

The effect observation of surgical treatment in gastrointestinal stromal tumor
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摘要 目的探讨胃肠道间质瘤(GIST)的手术治疗及预后。方法回顾性分析手术后经病理证实的GIST患者43例的临床资料。结果肿瘤完整切除患者(包括联合脏器切除患者)术后随访期间发生腹腔脏器复发、转移7例,死亡1例;带瘤生存4例,其中2例口服甲磺酸伊马替尼后病灶得到控制,肿瘤未进一步增大,其中带瘤生存时间最长为13个月。姑息性手术患者2例均死亡。结论手术切除是GIST治疗的首选,术前转移、Fletcher分级和是否口服甲磺酸伊马替尼与疾病的预后密切相关。 Objective To discuss the effect and prognosis of surgical treatment in gastrointestinal stromal tumor (GIST). Methods Retrospective analysed of the clinical data of 43 cases patients with GIST pathologically confirmed after surgery. Results Complete resection patients postoperative follow-up occurred during the the abdominal organs recurrence, metastasis in 7 cases, death one case;Alive with disease four cases, including two cases of oral mesylate imatinib lesionscontrol, the tumor had not increased further,with the survival time of up to 13 months. Patients with palliative surgery (2 cases) were fatal. Conclusion Surgical resection is the GIST treatment of choice, preoperative transfer, Fletcher classification and whether oral mesylate imatinib on behalf of nigeria and the prognosis of the disease is closely related.
作者 任锐 黄君
出处 《临床合理用药杂志》 2013年第13期8-9,共2页 Chinese Journal of Clinical Rational Drug Use
关键词 胃肠道间质瘤 手术方式 预后 Gastrointestinal stromal tumor Surgical approach Prognosis
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参考文献3

  • 1Miettinen M, Majidi M, Lasota J. Pathology and diagnostic criteria of gas-trointestinal stromal tumors(GISTs) : a review[ J]. Eur J Cancer,2002,38(suppl5):39-51. 被引量:1
  • 2Fletcher CD,Berman JJ, Corless C ,et al. Diagnosis of gastrointestinalgas-trointestinal stromal tumors : A consensus approach [ J ]. Hum Pathol,2002,33(5):459-465. 被引量:1
  • 3Hirota S,Isozaki K,Moriyaraa Y,et al. Gain-of-function mutations ofckit in human gastrointestinal stromal tumors [ J ]. Science, 1998, 279(5350):577 -580. 被引量:1

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