摘要
银屑病是人类最常见的一种慢性炎症性皮肤疾病,易复发,难治愈,发病机制不清楚,具有一定的遗传背景。它以角质形成细胞的过度增生和异常分化为特征,而这些病理特征经治疗后可好转。目前认为激发角质形成细胞异常反应的因素与细胞免疫异常有关,涉及树突状细胞、T淋巴细胞及免疫相关细胞因子和趋化因子,它们均参与银屑病的形成。免疫治疗作为目前治疗银屑病的最新手段,他的成功应用为人类其他免疫性疾病的治疗提供了可靠的依据。
Psoriasis is one of the most common human chronic skin diseases. It is characterized by excessive growth and abnormal differentiation of keratinocytes, but is fully reversible with appropriate therapy. The trigger of the keratinoeyte response is thought to be involved with the activation of the cellular immune system, with dendritic cells, T cells and various immune-related cytokines and chemokines implicated in pathogenesis. The newest therapeutic target for psoriasis is its immune components and the treatment may predict potential treatments for other inflammatory human diseases.
出处
《四川解剖学杂志》
2012年第4期50-54,共5页
Sichuan Journal of Anatomy
