摘要
目的探讨尼可地尔联合单硝酸异山梨酯治疗不稳定型心绞痛(UAP)的疗效与安全性。方法将2010年7月～2012年6月大连医科大学附属第一医院收治的94例UAP患者随机分为对照组(n=47)与观察组(n=47),所有患者均接受常规治疗,包括口服阿司匹林、β-受体阻滞剂、他汀类降脂药等,对照组在常规治疗基础上再联合使用单硝酸异山梨酯,观察组患者在常规治疗基础上再联合使用尼可地尔、单硝酸异山梨酯,治疗6周后对所有患者进行疗效以及不良反应发生率评价。结果①观察组临床症状改善情况、心电图改善情况显著优于对照组,两者相比差异有统计学意义(P<0.05)。②两组患者低血压发生率相比差异无统计学意义(P>0.05)。结论尼可地尔联合单硝酸异山梨酯可以显著改善UAP患者的临床症状,并使患者心电图恢复正常,同时未增加低血压发生率,因此该方案治疗UAP可以取得理想的效果。
Objective To investigate the therapeutic efficacy and safety of Nicorandil combined with Isosorlyide Mononitrate in the treatment of unstable angina （UAP）. Methods 94 cases of UAP who were admitted into the First Hospital Affiliated to Dalian Medical University from July 2010 to June 2012 were divided into control group （n = 47） and observation group （n = 47） randomly, and all patients received conventional therapy, including oral aspirin, β- blockers, statin lipid-lowering drugs and so on. Moreover, the control group received Isosorbide Mononitrate, while the observation group was given Nicorandil, Isosorbide Mononitrate based on the conventional therapy. The therapeutic efficacy and incidence of adverse reactions were evaluated after 6 weeks of treatment. Results ①The improvement of clinical symptoms, electrocardiogram of the observation group were significantly better than those of the control group respectively （P 〈 0.05）. ②There was no significant difference in the incidence rate of hypotension between the control group and the observation group （P 〉 0.05）. Conclusion Nicorandil combined with Isosorbide Mononitrate in the treat- ment of UAP is able to improve the clinical symptoms crease the incidence of hypotension simultaneously, so al effect. significantly, restore electrocardiogram to normal, and don＇t inthis treatment program in the treatment of UAP may obtain ideal effect.
出处
《中国医药导报》
CAS
2013年第13期78-79,82,共3页
China Medical Herald
基金
国家自然科学基金资助项目(项目编号:810250015)
