阿托伐他汀对新诊断血脂正常2型糖尿病超敏C反应蛋白的影响被引量：1

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摘要目的观察阿托伐他汀对血脂正常的新诊断2型糖尿病无大血管病变患者超敏C反应蛋白的影响。方法入选64例随机分为治疗组31例和对照组33例,两组患者均在饮食治疗及生活方式干预基础上加用降糖治疗,治疗组加用阿托伐他汀20mg每晚一次,共1年。对照组给予安慰剂。测两组空腹血糖(FPG),餐后2小时血糖(PPG),糖化血红蛋白(HbA1c),总胆固醇(TC)、甘油三酯(TG),低密度脂蛋白(LDL-C),超敏C反应蛋白(hs-CRP)。结果治疗组和对照组治疗前后比较hs-CRP水平均显著下降,差异有统计学意义(P<0.05);治疗后治疗组hs-CRP水平显著低于对照组,差异有统计学意义(P<0.05)。结论在降血糖基础上联合使用阿托伐他汀调脂治疗可以降低超敏C-反应蛋白水平,对防治新诊断2型糖尿病发生大血管病变有积极作用。

作者胡朝晖刘加和何冬娟万金星刘香兰王春霞

机构地区浙江省衢州市人民医院内分泌科

出处《心脑血管病防治》 2013年第2期131-132,共2页 CARDIO-CEREBROVASCULAR DISEASE PREVENTION AND TREATMENT

关键词阿托伐他汀 2型糖尿病动脉内膜中层厚度

分类号 R587.1 [医药卫生—内分泌]

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参考文献4

1中华心血管病杂志编辑委员会血脂异常防治专家组血脂异常防治建议[J].中华心血管病杂志,1997,25(1):169-175. 被引量：1
2Roseusen RS Tang hey CC Anti-atherombotic properties of statins; implica- tions for cardiovascular event reduction[J]. JAMA, 1998,279(20) : 1643 - 1650. 被引量：1
3李秀钧,邬云红.糖尿病是一种炎症性疾病?[J].中华内分泌代谢杂志,2003,19(4):251-253. 被引量：253
4Marroquin OC, Kip KE, Mulukutla SR, et al. Imtlamroation, endothelial cell activation, and coronary microvascular dysftmtion in women with chest pain and obstructive coronary artery disease[J]. Am Heart,2005,150(6): 109- 115. 被引量：1

二级参考文献17

1Schmidt MI, Duncan BB, Scharrct AR, et al. Markers of inflammation and prediction of diabetes mellitus in adults (Atherosclerosis Risk in Communities study): a cohort study. Lancet, 1999,353:1649-1652. 被引量：1
2Barzilay JI, Abraham L, Heckbert SR, et al. The relation of markers of inflammation to the development of glucose disorders in the elderly: the Cardiovascular Health Study. Diabetes, 2001,50:2384-2389. 被引量：1
3Pradhan AD, Manson JE, Rifai N, et al. C-reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitus. JAMA, 2001,286:327-334. 被引量：1
4Festa A, Ralph BD, Russell PT, et al. Elevated levels of acute phase proteins and plasminogen activator inhibitor-1 (PAI-1) predict the development of type 2 diabetes mellitus: the insulin resistance atherosclerosis study (IRAS). Diabetes, 2000,49(Suppl 1):A24-A25. 被引量：1
5Duncan BB, Schmidt MI, Offenbacher S, et al. Factor Ⅷ and other hemostasis variables are related to incident diabetes in adults. Diabetes care, 1999,22:767-772. 被引量：1
6Lindsay RS, Krakoff J, Hanson RL, et al. Gamma globulin levels predict type 2 diabetes in the Pima Indian population. Diabetes, 2001,50:1598-1603. 被引量：1
7Mcneely MJ, Bokyko EJ, Weigle DS, et al. Association between baseline plasma leptin levels and subsequent development of diabetes in Japanese Americans. Diabetes Care, 1999,22:65-70. 被引量：1
8Yuan M, Konstantopoulos N, Lee J, et al. Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of IKKbeta. Science, 2001,293:1673-1677. 被引量：1
9Hundal RS, Petersen KF, Mayerson AB, et al. Mechanism by which high-dose aspirin improves glucose metabolism in type 2 diabetes. J Clin Invest, 2002,109:1321-1326. 被引量：1
10Freeman DJ, Norrie J, Sattar N, et al. Pravastatin and the development of diabetes mellitus, evidence for a protective treatment effect in the West of Scotland Coronary Prevention Study. Circulation, 2001,103:357-362. 被引量：1