摘要
目的评价反复自然流产患者封闭抗体(BA)和抗心磷脂抗体(ACA)检测的临床意义。方法 356例反复自然流产组患者采用ELISA法检测血清BA阴性率、ACA阳性率,并与对照组进行比较。结果反复自然流产组BA阴性率81.7%(291/356)、ACA阳性率27%(96/356),与对照组比较,差异有统计学意义(P<0.05);原发性自然流产组BA阴性率84.9%(197/232)、ACA阳性率31%(72/232),与继发性自然流产组比较,差异有统计学意义(P<0.05)。结论 BA的缺乏及ACA的产生与反复自然流产有关,且在原发自然流产中更明显。对原因不明的反复自然流产患者应进BA、ACA检测。
Objective To evaluate the clinical significance of blocking antibody（BA）and anticardiolipin antibody（ACA） detection in patients with recurrent spontaneous abortion. Methods 356 cases of recurrent spontaneous abortion group were detected by ELISA in serum of BA negative rate, positive rate of ACA and compared with the control group. Results Recurrent spontaneous a- bort/on group BA negative rate was 81. 7%（291/356）, ACA positive rate was 27% （96/356） compared with control group, the difference was statistically significant（P〈0.05） ; primary spontaneous abortion group BA negative rate was 84. 9% （197/232）, ACA positive rate was 31 % （72/232） compared with secondary spontaneous abortion group,the difference was statistically signifi- cant（P〈0.05）. Conclusion BA deficiency and ACA associated with recurrent spontaneous abortion,which was more obvious in the primary natural abortion. Patients with unexplained recurrent spontaneous abortion should be performed in BA, ACA detection.
出处
《国际检验医学杂志》
CAS
2013年第7期773-773,775,共2页
International Journal of Laboratory Medicine
关键词
抗体
封闭
抗体
抗磷脂
流产
习惯性
antibodies,blocking
antibodies,antiphospholipid
abortion,habitual
