摘要
目的:观察雷公藤多甙联合阿维A治疗寻常型银屑病的临床疗效及对外周血T细胞亚群(CD3+、CD4+、CD8+、CD4+/CD8+)水平的影响。方法:将60例寻常型银屑病患者随机分为治疗组和对照组。两组患者均给予阿维A常规治疗,治疗组在阿维A常规治疗的基础上给予雷公藤多甙治疗。治疗前后测定患者血清T细胞亚群(CD3+、CD4+、CD8+、CD4+/CD8+)水平,连续治疗8周后评价疗效。结果:治疗组临床疗效总有效率为93.3%,显著高于对照组的70.0%,组间差异有统计学意义(P<0.05);治疗后,治疗组和对照组CD3+、CD4+、CD4+/CD8+水平显著上升,与治疗前比较,差异有统计学意义(P<0.01),且治疗组较对照组CD3+、CD4+、CD4+/CD8+水平显著上升,差异有统计学意义(P<0.01)。治疗后,治疗组和对照组CD8+水平均显著下降,与治疗前比较,差异有统计学意义(P<0.01),而治疗后组间CD8+水平比较,差异无统计学意义(P>0.05)。两组均无严重不良反应发生。结论:雷公藤多甙联合阿维A治疗寻常型银屑病能显著提高临床疗效,且安全可靠,并能抑制T细胞活化及增殖,可以通过调节CD4+/CD8的比值来达到调节机体免疫功能的作用。
Objective： To observe the clinical efficacy and impact on peripheral blood T cell subsets （CD3＋, CD4＋, CD8＋, CD4＋/CD8＋） of tripterygium glycosides and acitretin in psoriasis vulgaris. Methods： 60 patients with psoriasis vulgaris were ran- domly divided into treatment and control group. The patients in two groups were treated with acitretin, on the basis of which, the treatment group was treated with tripterygium glycosides. The peripheral blood T cell subsets （CD3＋,CD4＋,CD8＋ and CD4＋/ CD8＋） levels of patients were detected, before and after treatment. The clinical efficacy was evaluated after 8 weeks. Results： The effective rate of the treatment group was 93.3%, which was significantly higher than that of the control group （70.0%）, with significant difference （P〈0.05）; After treatment, the CD5＋, CD4＋ and CD4＋/CD8＋ levels in treatment and control group in- creased significantly, and the difference were significant（P〈0.O1）; and the improvement of CD3＋,CD4＋ and CD4＋/CD8＋ levels in treatment group were higher than that in control group（P〈0.01）. After treatment, the CD8＋ levels in treatment and control group decreased significantly, with significant difference （P〈0.01）; and the difference on CD8＋ levels between the treatment and control group was not significant （P〉0.05）. There were no serious adverse events in the two groups. Conclusions： The triptery- gium glycosides and acitretin can significantly improve the clinical efficacy in psoriasis vulgaris, inhibit T-cell activation and proliferation, and regulate immune function by adjusting the ratio of CD4＋/CD8＋.
出处
《中医药导报》
2013年第4期1-3,6,共4页
Guiding Journal of Traditional Chinese Medicine and Pharmacy
关键词
寻常型银屑病
雷公藤多甙
阿维A
疗效观察
T细胞亚群
Psoriasis vulgaris
Tripterygium glycosides
Acitretin
Clinical efficacy
T cell subsets
