摘要
目的:探讨我院抗菌药物使用强度(AUD)的计算方法及指标制定。方法:将我院2011年使用抗菌药物的出院患者按年龄分成新生儿组、儿童组和成人组,统计使用抗菌药物的出院患者例数、各组患者比例、新生儿组和儿童组患者的平均体质量、平均体质量与70kg的转换率,以限定日剂量(DDD)乘以转换率计算新生儿的DDD和儿童的DDD。采用两种方法计算AUD,一种方法是所有出院患者的AUD均以DDD计算,以AUD1表示;另一种方法是新生儿组、儿童组和成人组患者的AUD分别以各自的DDD计算,以AUD2表示。2012年的AUD指标制定为各月应力争控制在2011年的AUD1以下。结果:我院2011年共有18007例出院患者使用抗菌药物,其中新生儿组、儿童组和成人组患者比例分别为15.67%、25.92%和58.41%。新生儿组和儿童组患者的平均体质量分别为(3±1)kg和(10±6)kg。2011年AUD1为26DDDs/100人/天,AUD2为95DDDs/100人/天。2012年的AUD指标为各月AUD应力争控制在26DDDs/100人/天以下。结论:在我院出院患者中,成人、新生儿和儿童均是抗菌药物的主要使用者;我院的AUD指标应该在综合医院和儿童医院的AUD之间。新生儿和儿童的AUD分别以新生儿的DDD和儿童的DDD计算,可以更准确地测算出其暴露于抗菌药物的广度和强度。
OBJECTIVE： To explore the method and target of antibiotics use density （AUD） in our hospital. METHODS： The discharged patients treated with antibiotics in our hospital in 2011 were divided into newborns group, children group, adults group according to ages. It was respectively counted that the number of discharged patients treated with antibiotics, the proportion of pa- tients in each group, average weights of newborns group and children group, the conversion rates of average weights and 70 kg. Newborns DDD and children DDD were equal to DDD multiplied respectively by the conversion rates. There were two methods of calculating AUD. AUD1 indicated that AUD was counted by DDD; AUD2 indicated that AUD were respectively counted by new- borns DDD, children DDD and adult DDD. The target of AUD each month in 2012 was to control below AUD1 in 2011. RESULTS： There were 18 007 discharged patients used antibiotics in our hospital in 2011. The constituent ratios of 3 groups were 15.67%, 25.92% and 58.41%, respectively. The average weights of newborns group and children group were （3 ＋ 1 ）kg and （10 ＋ 6）kg respectively. AUD1 was 26 DDDs/100 persons/day, and AUD2 was 95 DDDs/100 persons/day. The target of AUD was to control below 26 DDDs/100 persons/day each month in 2012. CONCLUSIONS： Adults, newborns and children are the main users of antibiotics among the discharged patients in our hospital, The target of AUD in our hospital should be between AUD of general hospital and children＇s hospital. It is to estimate the breadth and strength of newborns and children exposed to antibiotics exactly that AUD of newborns and children are respectively counted by newborns DDD and children DDD.
出处
《中国药房》
CAS
CSCD
2013年第18期1655-1657,共3页
China Pharmacy
