摘要
同源盒基因(HOX)家族中的HOXB4是造血细胞分化早期的重要调控因子,对调节造血干/祖细胞(HSPC)自我更新与分化间的平衡发挥重要作用。利用基因工程技术生产的TAT-HOXB4蛋白同样能有效扩增HSPC数量,并保留其在体内的分化潜能和长期再生潜能。本文对TAT-HOXB4蛋白是否会诱发白血病及其临床应用前景作一综述,讨论的问题包括HOX基因及HOXB4基因的结构特征,HOXB4在HSPC增殖分化中的作用,HOX基因与白血病、TAT-HOXB4蛋白等。
As one member of the HOX gene family, HOXB4 gene is a specific transcription factor, playing an important role in regulating balance between self-renewal and differentiation of hematopoietic stem/ progenitor ceils （HSPC）. Recombinant human TAT-HOXB4 protein carrying the protein transduction domain of the HIV transactivating protein （TAT） is comparable to that induced by the human HOXB4 retrovirus. TAT-HOXB4-expanded HSPC populations keep the potential of differentiation and long-term repopulation in vivo. In this article, whether TAT-HOXB4 protein can induce leukemia or can be applied to clinical treatment are reviewed, summarizing the structures of HOX gene and HOXB4 gene, role of HOXB4 in HSPC proliferention and differention, HOX gene and leukemia, TAT-HOXB4 protein, Clinical application prospect of TAT-HOXB4 protein and so on.
出处
《中国实验血液学杂志》
CAS
CSCD
北大核心
2013年第2期489-492,共4页
Journal of Experimental Hematology
