摘要
采用在体单细胞胞外记录的方法对比记录了老年猫及青年猫LGN、A18和PMLS区的细胞反应。使用发放率向量的方法表征神经元在多次Trial中一次的发放信息,同时采用视觉皮层细胞的一个重要的特性指标—反应不规则性,来衡量其在衰老过程中的变化情况,其中反应不规则性采用发放率向量的两种变异系数Cv和Cv2的平均值表示。结果发现,老化过程中LGN区细胞没有显著的变化,而其他两个区域的反应不规则性都受到衰老不同程度的影响,表现为反应不规则性的增大,说明老化对猫视皮层信息处理带来了损伤,本研究为其他神经体系在动物衰老过程中的变化研究提供实验依据。
In this research, we compared the visual neuron responses for LGN, A18 and PMLS of old and young cats with extracellular single-neuron recording techniques. We used firing rate vector to characterize information, and re- sponse irregularity of cells to evaluate the degeneration of visual characters. Response irregularity is characterized by means of the two coefficients of variation of firing rate vectors.. Cv and Cv2. We found that there was no significant change of the response irregularity in LGN areas during the aging process from young to old cats. But in the other two areas, neurons of old cats exhibited significantly larger response irregularity than those of young cats. The result indicated that the information processing function of advanced visual cortex was impaired by aging. This result also provids a reference for the research of the other neuronal system changes during aging process.
出处
《生物医学工程学杂志》
EI
CAS
CSCD
北大核心
2013年第2期229-233,共5页
Journal of Biomedical Engineering
基金
中央高校基本科研业务费专项资金资助项目(WK2100230002)
安徽医科大学博士科研启动基金资助项目(XJ200903)
关键词
老化
视觉通路
反应不规则性
猫
变异系数
信息处理
Aging
Visual pathway
Response irregularity
Cat
The coefficient of variation （Cv）
Information pro- cessing
