摘要
目的:观察麝香保心丸辅助治疗顽固性心绞痛的疗效和安全性。方法:将2010年10月-2011年12月住院治疗的顽固性心绞痛患者86例,随机均分为治疗组与对照组。对照组给予常规抗心绞痛治疗;治疗组在对照组治疗基础上口服麝香保心丸治疗,3粒/次,tid。2周后根据西雅图心绞痛量表观察两组患者的心绞痛发作情况、稳定状态及对患者治疗的满意程度,并观察患者躯体活动受限程度以及对疾病认识程度。结果:治疗组患者的心绞痛发作情况([79.3±9.5)分]、心绞痛稳定状态([83±7.9)分]、对治疗的满意度([90.2±7.5)分]、躯体活动受限程度([71.2±13.2)分]以及对疾病认识程度([77.4±8.2)分]均分别较对照组([88.3±11.4)、(63±11.5)、(78.2±9.4)、(89.2±7.8)、(71.2±13.7)分]显著改善(P<0.05)。两组均未见严重不良反应发生。结论:麝香保心丸辅助治疗顽固性心绞痛可有效改善患者生活质量,且安全性较好。
OBJECTIVE： To explore therapeutic efficacy of Shexiang baoxin pills in the treatment of refractory angina pectoris. METHODS： 86 cases of refractory angina pectoris during Oct. 2010--Dec. 2011 were randomized into treatment group and control group. Control group received conventional treatment of anti-angina; treatment group was given Shexiang baoxin pills orally, 3 pills each time, tid. on the basis of control group. The angina pectoris attacks, angina pectoris stable state and treatment satisfaction were observed in 2 groups after 2 weeks according to Seattle angina questionnaire （SAQ）; Limitation of body activity and improvement of the understanding of disease were also observed. RESULTS： Angina pectoris attack （79.3±9.5）, angina pectoris stable state （83 ±7.9）, satisfaction degree （90.2±7.5）, limitation of physical activity （71.2±13.2） and understanding of disease （77.4±8.2） in treatment group were obviously improved, compared to angina pectoris attack （88.3±11.4）, angina pectoris stable state （63±11.5）, satisfaction degree （ 78.2±9.4）, limitation of physical activity （89.2±7.8） and understanding of disease （71.2±13.7 ） of control group. There was no significant serious ADR found in both groups. There was statistical difference in therapeutic efficacy of 2 groups （P〈0.05）. CONCLUSION： Patients with refractory angina pectoris treated with Shexiang baoxin pills obtain sound curative effect, and there are rare adverse drug reactions.
出处
《中国药房》
CAS
CSCD
2013年第16期1493-1494,共2页
China Pharmacy
关键词
麝香保心丸
顽固性心绞痛
疗效
Shexiang baoxin pills： Refractory angina pectoris
Therapeutic effect
