摘要
目的:系统评价普萘洛尔与泼尼松比较治疗婴幼儿血管瘤的疗效与安全性。方法:计算机检索Pubmed、Medline、EM-base、Cochrane图书馆和中国期刊全文数据库、维普数据库,并追索已获文献的参考文献,纳入普萘洛尔与泼尼松比较治疗婴幼儿血管瘤的随机对照试验(RCT),对纳入文献采用RevMan5.0软件进行Meta分析。结果:共纳入6项RCT,合计373例患儿。Meta分析结果显示,普萘洛尔总有效率显著高于泼尼松[OR=5.72,95%CI(3.55,9.20),P<0.01],不良反应发生率显著低于泼尼松[OR=0.06,95%C(I0.03,0.11),P<0.01],两组比较差异均有统计学意义。结论:口服普萘洛尔治疗婴幼儿血管瘤与泼尼松比较,疗效和安全性均较好。
OBJECTIVE： To evaluate the therapeutic efficacy of propranolol vs. prednisone for infantile haemangiomas. METHODS： Pubmed, Medline, EMbase, Cochrane library, CNKI, VIP Database were searched, and the references of all included stud- ies were also traced with RCTs of propranolol vs. prednisone as object. Meta-analysis was conducted by using Rev Man 5.0 soft-ware using dominance ratio as response combined index. RESULTS： A total of 6 RCTs involving 373 patients were included. The total effective rate of propranolol was higher than that of prednisone [OR=5.72,95%CI（3.55,9.20）,P〈0.01], and the incidence of ADR of propranolol was lower than that of prednisone [OR=0.06,95 % CI （0.03, 0.11 ）, P〈0.01] ; there was statistical significance between 2 groups. CONCLUSION： Therapeutic efficacy of propranolol is better than prednisone for infantile haemangiomas.
出处
《中国药房》
CAS
CSCD
2013年第16期1478-1480,共3页
China Pharmacy
