期刊文献+

原发性胆汁性肝硬化的治疗 被引量:4

下载PDF
导出
摘要 原发性胆汁性肝硬化(PBC)是一种慢性肝内胆汁淤积性疾病。熊去氧胆酸(UDCA)是各种指南推荐且唯一经FDA批准的治疗PBC安全有效的药物。UDCA治疗对PBC患者的肝硬化进展、远期预后和生存率密切相关。对UDCA治疗无效患者应如何处理,目前尚无统一的方案。对乏力和瘙痒等症状的改善有助于提高PBC患者的生活质量。间充质干细胞移植可能对自身免疫性肝病有效,肝移植仍是治疗终末期PBC的唯一有效的方法。
作者 韩英 朱疆依
出处 《实用肝脏病杂志》 CAS 2013年第2期102-104,共3页 Journal of Practical Hepatology
  • 相关文献

参考文献20

  • 1Shapiro JM,Smith H,Schaffner F. Serum bilirubin:a prognostic factor in primary biliary cirrhosis. Gut,1979,20(2):137-140. 被引量:1
  • 2Beuers U. Drug insight:mechanisms and sites of action of ur- sodeoxycholic acid in cholestasis. Nat Clin Pract Gastroenterol Hepatol, 2006,3(6):318-328. 被引量:1
  • 3Ignazio G,Vincenzo OP,Piero P,et al. Long-term ursodeoxy- cholate improves circulating redox changes in primary biliary cirrhotic patients. Clin Biochem,2011,44(17-18):1400-1404. 被引量:1
  • 4Locke GR,Themeau TM,Ludwig J,et al. Time course of histo- logical progression in primary biliary cirrhosis. Hepatology, 1996,23( 1 ):52-56. 被引量:1
  • 5Angulo P,Dickson ER,Therneau TM,et al. Comparison of three doses of ursodeoxyeholie acid in the treatment of prima- ry biliary cirrhosis:a randomized trial. J Hepatol,1999,30(5): 830 - 835. 被引量:1
  • 6Ter Borg PC,Schalm SW,Hansen BE,et al. Prognosis of ur- sodeoxycholic acid-treated patients with primary biliary cirrho- sis. Results of a 10-yr cohort study involving 297 patients. Am J Gastroenterol,2006,101(9):2044-2050. 被引量:1
  • 7EASL Clinical Practice Guidelines: Management of cholestatic liver diseases. J Hepatol,2009,51(2):237-267. 被引量:1
  • 8Lindor KD,Gershwin ME,Poupon R,et al. Primary biliary cir- rhosis. Hepatology,2009,50( 1 ):291-308. 被引量:1
  • 9Kuiper EM, Hansen BE,de Vrios RA,et al. Improved prognosis of patients with primary biliary cirrhosis that have a biochemi- cal response to ursodeoxychohc acid. Gastroenterology,2009, 136(4):1281-1287. 被引量:1
  • 10Corpechot C,Abenavoli L, Rabahi N,et al. Biochemical response to ursodeoxycholic acid and long-term prognosis in primary biliary cirrhosis. Hepatology,2008,48(3):871-877. 被引量:1

同被引文献55

  • 1胆汁淤积性肝病诊断治疗专家委员会.胆汁淤积性肝病诊断治疗专家共识2013[J].中华肝脏病杂志,2014,22(1). 被引量:26
  • 2谢雯,成军.《胆汁淤积性肝病诊断治疗专家共识2013》解读[J].中华肝脏病杂志,2014,22(1). 被引量:15
  • 3侯岩峰,张源潮.皮肌炎并发肺间质病变[J].中国实用内科杂志,2005,25(6):558-560. 被引量:8
  • 4田耀洲,宣估,曹鹏,等.化肝通络方对原发性胆汁性肝硬化的抗纤维化作用及机制探讨[C]//第二十五届全国中西医结合消化系统疾病学术会议论文集.南昌:中国中西医结合学会消化系统疾病专业委员会,2013:430. 被引量:2
  • 5Nguyen D L,Juran B D,Lazaridis K N,et al.Primary biliary cirrhosis[J].Best Pract Res Clin Gastroenterol,2010,24(5):647-654. 被引量:1
  • 6Rautiainen H,Karkkainen P,Karvonen A L,et al.Budesonide combined with UDCA to improve liver histology in primary biliary cirrhosis:a three-year randomized trial[J].Hepatology,2005,41(4):747-752. 被引量:1
  • 7Angulo P,Jorgensen R A,Keach J C,et al.Oral budesonide in the treatment of patients with primary biliary cirrhosis with a suboptimal response to ursodeoxycholic acid[J].Hepatology,2000,31(2):318-323. 被引量:1
  • 8Hempfling W,Grunhage F,Dilger K,et al.Pharmacokinetics and pharmacodynamic action of budesonide in early and late stage primary biliary cirrhosis[J].Hepatology,2003,38(1):196-202. 被引量:1
  • 9Honda A,Ikegami T,Nakamuta M,et al.Anticholestatic effects of bezafibrate in patients with primary biliary cirrhosis treated with ursodeoxycholic acid[J].Hepatology,2013,57(5):1931-1941. 被引量:1
  • 10Takeuchi Y,Ikeda F,Fujioka S,et al.Additive improvement induced by bezafibrate in patients with primary biliary cirrhosis showing refractory response to ursodeoxycholic acid[J].J Gastroenterol Hepatol,2011,26(9):1395-1401. 被引量:1

引证文献4

二级引证文献21

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部