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维生素D与慢性肾脏疾病 被引量:7

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摘要 1,25-二羟维生素D3〔1,25(OH)2D3〕是维生素D3的激素(活性)形式,其传统作用是维持钙磷代谢及骨骼结构。随着研究的深入,人们逐渐认识到它更广泛的生理作用,除了调节钙磷代谢外,在肾脏、心血管及免疫系统组织中作为分化及抗增殖因子起到更重要的作用〔1~5〕。在慢性肾脏病(CKD)患者中,维生素D的非传统作用还包括调节肾素.血管紧张素系统(RAS)、核因子(NF)-κB途径,这两种途径包含了广泛的病理过程。维生素D的缺乏会使其传统及非传统作用受到影响。最近研究证明,给维生素D缺乏的患者以充足的维生素D,能够降低发病率及死亡率哺。这些发现将有助于扭转维生素D在慢性肾衰竭患者中的使用方向,不再是单一治疗甲状旁腺功能亢进症。这些研究结果给维生素D缺乏的治疗提供了新的方向。
出处 《中国老年学杂志》 CAS CSCD 北大核心 2013年第7期1710-1712,共3页 Chinese Journal of Gerontology
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参考文献26

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