摘要
肝纤维化是多种慢性肝病向肝硬化发展的必经阶段,是所有慢性肝病的共同病理基础.血小板衍生生长因子(platelet-derived growth factors,PDGFs)是由4个亚基同型或异型两两相互聚合形成的二聚体,现已证实其与肝纤维化的形成、发展密切相关.本文就PDGFs及其受体在肝纤维化的发生、治疗及其研究进展作一综述.
Liver fibrosis occurs as a result of various injurious processes and is the common pathologic basis for all chronic hepatic diseases. Platelet-derived growth factors （PDGFs） are homodimers or heterodimers consisting of two polypep-tide chains. Previous studies have proved that PDGFs are closely related to the occurrence and development of liver fibrosis. In this article, we review the advances in research on the role of PDGFs and their receptor in pathogenesis and therapy of liver fibrosis.
出处
《世界华人消化杂志》
CAS
北大核心
2013年第9期773-778,共6页
World Chinese Journal of Digestology
