摘要
目的探讨重组人干扰素-γ（IFN-γ）联合激素治疗特发性肺间质纤维化（IPF）的临床效果。方法选择36例IPF患者，随机分为A、B两组，每组各18例，A组根据患者的体质量每日予以泼尼松0．5mg／kg，4周后剂量减半，3～4个月内剂量减至10～20mg／d。B组患者在A组治疗的基础上，每天予以皮下注射200U IFN-γ。治疗1个月后对两组患者的治疗效果进行比较。结果治疗1个月后，B组患者的临床症状及肺弥散功能的改善情况明显优于A组，差异有统计学意义（P〈0．05）。两组患者的血清Ⅲ型胶原（Ⅲ—C）、Ⅳ型胶原（Ⅳ-C）、透明质酸（HA）水平均显著低于治疗前（P〈0．05）；且治疗后B组患者的血清Ⅲ-C、Ⅳ-C、HA显著低于A组，差异有统计学意义（P〈0．05）。结论IPF患者在激素治疗的基础上予以皮下注射IFN-γ，能明显改善其临床症状及肺纤维化进程，治疗效果优于单纯使用激素者。
Objective To investigate the clinical effect of recombinant human interferon-γ（ IFN-γ） combined with hormone on idiopathic pulmonary fibrosis（IPF）. Methods Thirty-six patients with IPF were randomly divided into group A and B, with 18 patients in each group. Patients in group A were given Prednisone （0. 5 mg/kg）every day according to body weight, the dose was halved after four weeks, the dose was reduced to 10 -20 mg/d in 3 -4 months treatment. Patients in group B were given subcutaneous injection of IFN-γ/200 U, besides the same treatment of group A. The clinical effect of the two groups were compared one month after treatment. Results The clinical symptoms and improvement in pulmonary diffusion of group B were better than those in group A, the differences were statistically significant （P 〈 0. 05 ）. Level of serum Ⅲ-C、Ⅳ-C and HA of the two groups were lower than before treatment significantly （P 〈 0. 05） ,and level of serum Ⅲ-C、Ⅳ-C and HA of group B were lower than those of group A, the differences were statistically significant （P 〈 0. 05）. Conclusions The effect of subcutaneous injection of IFN-γ, combined with hormone on IPF is better than hormone therapy only.
出处
《中国实用医刊》
2013年第8期20-21,共2页
Chinese Journal of Practical Medicine
关键词
特发性肺间质纤维化
重组人干扰素-γ
激素
临床疗效
Idiopathic pulmonary fibrosis
Recombinant human interferon-γ
Hormone
Clinical effect
