不同剂量阿托伐他汀对急性心肌梗死患者择期行PCI后PIGF及心肌灌注的影响被引量：1

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摘要目的观察不同剂量阿托伐他汀对急性心肌梗死(AMI)患者择期行经皮冠脉介入治疗(PCI)后血清胎盘生长因子(PIGF)及心肌灌注的影响,探讨阿托伐他汀改善心肌灌注与其剂量相关的可能机制。方法选择120例择期行PCI的AMI患者,随机分为A组43例、B组40例、C组37例,分别于行PCI前1周开始口服阿托伐他汀20、40、60 mg/d,每晚1次;并于PCI前、PCI后2周检测其血清PIGF,PCI后2周行心肌核素显像检查,计算心肌灌注显像积分。结果三组PCI前血清PIGF无统计学差异(P均>0.05);PCI后2周,C组PIGF明显低于B组、A组(P均<0.05)。PCI后2周,心肌灌注显像积分C组明显低于B组及A组(P均<0.05)。结论阿托伐他汀可能通过抗炎作用改善AMI患者的心肌灌注,大剂量阿托伐他汀改善择期行PCI后患者心肌灌注的作用优于小剂量阿托伐他汀,故建议此类患者PCI前行强化阿托伐他汀治疗。

作者李勇王巧芝郑群张颖轩张俊岭李拥军

机构地区哈励逊国际和平医院河北医科大学第二医院

出处《山东医药》 CAS 2012年第45期39-41,共3页 Shandong Medical Journal

基金衡水市科学技术研究与发展计划项目(09002A)

关键词冠状动脉疾病经皮冠脉介入治疗阿托伐他汀胎盘生长因子心肌灌注

分类号 R541.4 [医药卫生—心血管疾病]

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