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饮酒对腔镜检查患者丙泊酚镇静效应的影响

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摘要 目的探讨低风险饮酒对腔镜检查患者的丙泊酚靶控输注镇静效应的影响。方法无痛腔镜检查患者286例,ASAI或Ⅱ级,年龄35~72岁,分为低风险饮酒组(D组,n=117例)和非饮酒组(N组,n=169例)。受试对象排除相关非处理因素,仅接受丙?自酚TCl镇静,血浆靶浓度设定为3.5ug/mL,观察并记录每组每分钟HR、SPO2、NIBP以及警觉/镇静(OAA/S)评分,停药后靶血浆药物浓度、靶效应室药物浓度的不良事件和浓度衰减发生率;OAA/S评分达0分所用时间,所需丙泊酚用量,血浆靶浓度与效应室靶浓度平衡,即刻停药到OAA/S评分恢复至5分所用时间。结果OAA/S评分达0分所用时间D组(483±205)s,N组(507±195)s,达0分所需丙泊酚用量D组为(2.2±0.5)mg/kg,N组为(2.3±0.8)mg/kg,OAA/S评分恢复为5分所用时间D组(530±175)S,N组为(527±168)S。结论低风险饮酒的患者对丙泊酚TCI镇静效应无明显影响。
作者 邓晓钧 王磊
出处 《中国卫生产业》 2013年第10期83-84,共2页 China Health Industry
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参考文献7

  • 1World Health Organization. International guide for monitoring alcohol consumption and related harm. Geneva: WHO, 2000. 被引量:1
  • 2李安学,董惠翔,杨兵,刘玉春,刘忠民.嗜酒者丙泊酚静脉全麻药量及效应的临床观察[J].临床麻醉学杂志,2008,24(7):583-585. 被引量:14
  • 3Servin Fs, Bougeois B, Gomeni R,etal, Pharmaco.Kinetres of propofol administered by target-controlled infusion to alcoholic patients[J]. A nesthesiology, 2003, 99: 576-585. 被引量:1
  • 4Lyons D,Whitlow CT, smith HR, et al.Brain imaging: Functional consequences of ethanol in the central nervous system[J].Recent Dev Alcohol, 1998, 14: 253-284. 被引量:1
  • 5Maiorano G, Bartolomucci F,Contursi V, et al.Noninvasive detection of vascular dysfuaction in alcoholic patients[J]. Hypertens, 1999, 12: 137-144. 被引量:1
  • 6Morvai V, Ungvary G.Effect of chromic exposure to alcohol on the circulation of rats of different ages[J].Aeta Physiol acad Sei Hung, 1979, 53: 433-441. 被引量:1
  • 7Fassoulaki A, Farinotti R, Servin F, etal. Chronic alcoholism increases the induction dose of propofol in humams[J].Anesth Analg, 1993,77: 553-556,. 被引量:1

二级参考文献15

  • 1郭坤亮,季克良,王昌禄.酒精代谢及其相关基因遗传多态性[J].酿酒科技,2005(7):36-38. 被引量:9
  • 2孙庆文.酒精饮料在人体内的代谢及适宜饮量[J].酿酒科技,2006(8):126-127. 被引量:16
  • 3Fassoulaki A,Farinotti R,Servin F, et al. Chronic alcoholism increases the induction dose of propofol in humans. Anesth Analg, 1993,77 : 553-556. 被引量:1
  • 4Servin FS, Bougeois B, Gomeni R, et al. Pharmacokinetics of propofol administered by target-controlled infusion to alcoholic patients. Anesthesiology, 2003,99 : 576-585. 被引量:1
  • 5Cichoz-Lach H, Partycka J, Nesina I, et al. Genetic polymorphism of alcohol dehydrogenase 3 in digestive tract alcohol damage. Hepatogastroenterology, 2007,54 :1222-1227. 被引量:1
  • 6Montano Loza AJ,Ramirez Iglesias MT, Perez Diaz I,et al. Association of alcohol-metabolizing genes with alcoholism in a Mexican Indian (Otomi) population. Alcohol, 2006, 39 : 73-79. 被引量:1
  • 7Zintzaras E, Stefanidis I, Santos M, et al. Do alcohol-metabolizing enzyme gene polymorphisms increase the risk of alcoholism and alcoholic liver disease? Hepatology, 2006,43 : 352- 361. 被引量:1
  • 8Konishi M, Ishii H. Role of microsomal enzymes in development of alcoholic liver diseases. J Gastroenterol Hepatol, 2007,22(Suppl 1) S7-10. 被引量:1
  • 9Hiraoka H, Yamamoto K, Miyoshi S, et al. Kidneys contribute to the extrahepatic clearance of propofol in humans, but not lungs and brain. Br J Clin Pharmacol, 2005,60 : 176-182. 被引量:1
  • 10Al-Jahadai WS, Yamamoto K, Hiraoka H,et al. Prediction of total propofol clearance based on enzyme activities in microsomes from human kidney and liver. Eur J Clin Pharmacol, 2006,62:527-533. 被引量:1

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