摘要
目的观察伴有全频听力损失的突发性耳聋患者高压氧治疗后听力的动态变化特点。方法经耳鼻喉科确诊的82例全频听力损失的突发性耳聋患者，经患者知情同意，并签署知情同意书后分为对照组40例、高压氧组（HBO组）42例。对照组给予常规治疗：10mg地塞米松静脉输液3d后，减为5mg地塞米松静脉输液3d；前列地尔10μg静脉滴注，1次／d，连续14d；维生素B，100mg、B。：500Ixg肌肉注射，1次／d，连续30d。HBO组在常规治疗基础上给予HBO治疗，1次／d，10次为1个疗程，连续治疗2个或4个疗程后复查纯音测听。结果治疗2个疗程后，与对照组的低频听力提高值[（24．68±3．87）dB]相比，HBO组的低频听力提高值[（38．16±5．88）dB]增加，差异有统计意义（P〈0．01）；与对照组的高频听力提高值[（10．49±2．34）dB]相比，HBO组的高频听力提高值[（12．33±2．98）dB]有一定增加，但差异无统计学意义（P〉0．05）；多数患者以低频听力改善为主，恢复较快；与对照组的总有效率（62．5％）比较，HBO组总有效率（80．9％）提高，但差异无统计学意义（P〉0．05）。与低频听力改善相比，高频听力恢复比较缓慢，在第4个疗程结束时，患者纯音测听主要以高频听力改善为主；与对照组的低频听力提高值[（37．80±5．91）dB]相比，HBO组低频听力提高值[（46．51±6．11）dB]增加，差异有统计意义（P〈0．05）；与对照组的高频听力提高值[（9．71±1．52）dB]相比，HBO组的高频听力值[（19．82±4．13）dB]增加，差异有统计意义（P〈0．01）；与对照组的总有效率（67．5％）比较．HBO组的总有效率（85．7％）提高，但差异无统计学意义（P〉0．05）。结论HBO治疗可改善全频听力损失突发性耳聋患者的低频或／和高频听力水平，提高治疗的总有效率。
Objective To observe the dynamic characteristics of hearing recovery in full-frequency heating loss in the patients with sudden deafness following HBO therapy. Methods Eighty-two cases of ruB- frequency heating loss confirmed by ENT specialists were randomly divided into the control group （40 cases ） and the HBO therapy group （42 cases）. The patients in the control group were given routine treatment, i.e. 10 mg of dexameihasone intravenous infusion for first 3 days, then, 5 mg of dexamethasone for another 3 days. Besides, the patients were administered 10 μg alprostadil intravenous infusion, once a day for 14 consecutive days; 100 mg of Vitamin B1, 500 txg of B12 muscular injection, once day for 30 consecutive days. The patients in the HBO therapy group were given HBO therapy ＋ routine treatment, once a day, 10 sessions a treatment course. Following 2 or 4 consecutive treatment courses, pure tone audiometry was performed. Results After 2 courses of HBO therapy, low-frequency average hearing level [ （38.16 ± 5.88 ）dB ] increased for the patients in the HBO therapy group, when compared with that of the patients in the control group （24.68 ±3. 87） dB], with statistical significance （P 〈 0.01 ）. On the other hand, high-frequency average hearing level [ （ 12.33±2.98）dBl increased to some extent for the patients in the HBO therapy group, when compared with that of the patients in the control group [ （ 10.49 ± 2.34） dB ] , without statistical significance （P 〉 0.05）. For most patients, low-frequency hearing level improved more markedly and recovered more quickly. Total effective rate （80.9%） for the HBO group increased, when compared with that of the control group （62.5%） , but without statistical significance （ P 〉 0.05 ）. When compared with low-frequency hearing level, high-frequency hearing level recovered more slowly. At the end of the 4 courses, pure tone monitoring indicated that improvement was seen mainly in high-frequency hearing level. For the patients
出处
《中华航海医学与高气压医学杂志》
CAS
CSCD
北大核心
2013年第1期32-35,共4页
Chinese Journal of Nautical Medicine and Hyperbaric Medicine
关键词
突发性耳聋
全频听力损失
高压氧
地塞米松
前列地尔
Sudden deafness
Full-frequency hearing loss
Hyperbaric oxygen
Dexamethasone
Alprostadil
