摘要
甘肃为我国胃癌高发区，胃癌病死率居全国之首，安全有效的治疗是研究重点。近年来，随着对肿瘤分子生物学机制研究的不断深入，肿瘤的靶向治疗已成为研究的新方向。大量研究结果表明：环氧合酶（COX）的过度表达在肿瘤的发生、发展中起着重要作用，非甾体类抗炎药塞来昔布是一种新型COX-2选择性抑制剂，可明显降低消化道肿瘤的发病率。它通过抑制肿瘤生长和肿瘤新生血管生成，诱导肿瘤细胞凋亡，逆转多药耐药，增强化疗药的细胞毒作用和放射敏感性，与化、放疗产生协同作用，从而抑制肿瘤的发生、发展。因此，以COX-2为特异靶点的治疗策略有望为胃癌治疗提供新的思路，具有良好的临床应用前景。
Gansu province is a high incidence area of gastric cancer, and the mortality caused by gastric cancer ranks first in China. A safe and effective treatment of gastric cancer is the key point in the research. In recent years, tumor-targeted therapy has become a new research direction along with the gradually increased understanding of the molecular biology of cancer mechanism. Several studies have shown that increased expression of cyelooxygenase （COX） -2 plays an important role in the occurrence and development of malignant tumor. Celecoxib, a non-steroidal anti-inflammatory drug, is a novel COX-2 selective inhibitor which can significantly reduce the incidence of gastrointestinal malignancy, and inhibit tumorigenesis through inhibiting tumor growth and tumor angiogenesis, inducing the apoptosis of tumor cells, reversing multidrug resistance, enhancing the cytotoxicity and radiosensitivity of chemotherapy drugs, and producing synergistic effects with combining chemotherapy and radio- therapy. Therefore, celecoxib has the potential to be the treatment of choice for gastric cancer.
出处
《中华消化外科杂志》
CAS
CSCD
北大核心
2013年第4期317-320,共4页
Chinese Journal of Digestive Surgery
关键词
胃肿瘤
塞来昔布
环氧合酶-2
Gastric neoplasms
Celecoxib
Cyclo-oxygenase - 2
