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听力图正常耳鸣患者的隐匿性听力损失:耳鸣起源的启示 被引量:10

Hidden hearing loss in tinnitus patients with normal audiograms:implications for the origin of tinnitus
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摘要 目的:通过分析听力图正常耳鸣患者听性脑干反应(ABR)的特点检测可能存在的隐匿性听力损失,探讨耳鸣的起源。方法:对2010-2012年因单纯性耳鸣就诊于我院的40例患者与15例正常对照者进行纯音听阈、ABR听阈、Ⅰ波及Ⅴ波波幅的检测,并分析其结果。结果:耳鸣患者纯音听阈及ABR阈值与正常对照者无明显差异,但耳鸣患者ABRⅠ波波幅下降,Ⅴ波波幅则恢复正常水平。结论:听力图正常的耳鸣患者在初级听神经水平存在隐匿性听力损失,脑干水平的稳态维持机制可能是产生耳鸣的基础。 Objective:To investigate hidden hearing loss in tinnitus patients with normal audiograms by means of auditory brainstem response(ABR) and explore the origin of tinnitus.Method:Pure tone thresholds,ABR thresholds,amplitude of wave Ⅰ and wave Ⅴ of ABR were analyzed in 40 tinnitus patients and 15 controls.Result:There was no significantly difference in pure tone thresholds and ABR thresholds between those tinnitus patients and controls while a reduced amplitude of wave Ⅰ and normal amplitude of wave Ⅴ of ABR in the tinnitus patients became evident.Conclusion:Tinnitus patients with normal audiograms have hidden hearing loss at the level of primary auditory nerve and the generation of tinnitus is likely attributed to a homeostatic response of neurons in brainstem.
出处 《临床耳鼻咽喉头颈外科杂志》 CAS 北大核心 2013年第7期362-365,共4页 Journal of Clinical Otorhinolaryngology Head And Neck Surgery
基金 国家自然科学基金资助项目(No:81170921 81200743)
关键词 耳鸣 纯音测听 听性脑干反应 听力损失 tinnitus pure tone audiometry auditory brainstem response hearing loss
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  • 1ROBERTS L E, EGGERMONT J J, CASPARY D M, etal. Ringing ears: the neuroscience of tinnitus [J]. J Neurosci,2010,30:14972-14979. 被引量:1
  • 2KALTENBACH J A. Tinnitus: Models and meeha- nisms[J]. Hear Res,2011, 276:52-60. 被引量:1
  • 3SANCHEZ T G, MEDEIROS I R, LEVY C P, et al. Tinnitus in normally hearing patients: clinical aspects and repercussions [J].Braz J Otorhinolaryngol, 2005, 71:427-431. 被引量:1
  • 4KEHRLE H M, GRANJEIRO R C, SAMPAIO A L, et al. Comparison of auditory brainstem response re- sults in normal-hearing patients with and without tin- nitus[J]. Arch Otolaryngol Head Neck Surg, 2008, 134:647-651. 被引量:1
  • 5SCHAETTE R, MCALPINE D. Tinnitus with a nor- mal audiogram: physiological evidence for hidden hearing loss and computational model[J]. J Neurosci, 2011, 31:13452-13457. 被引量:1
  • 6KUJAWA S G, LIBERMAN M C. Adding insult to injury: cochlear nerve degeneration after "temporary" noise-induced hearing loss[J]. J Neurosci, 2009, 29:14077-14085. 被引量:1
  • 7LIN H W, FURMAN A C, KUJAWA S G, et al. Primary neural degeneration in the Guinea pig cochlea after reversible noise-induced threshold shift [J]. J Assoe Res Otolaryngol,2011, 12:605-616. 被引量:1
  • 8EL-BADRY M M, MCFADDEN S L. Electrophysio- logical correlates of progressive sensorineural patholo- gy in carboplatin-treated chinchillas[J]. Brain Res, 2007, 1134:122-130. 被引量:1
  • 9TABERNER A M, LIBERMAN M C. Response proper- ties of single auditory nerve fibers in the mouse[J]. J Neurophysiol, 2005, 93 : 557 - 569. 被引量:1
  • 10RAUSCHECKER J P, LEAVER A M, MUHLAU M. Tuning out the noise: limbic-auditory interactions in tinnitus[J]. Neuron, 2010, 66:819-826. 被引量:1

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