摘要
目的探讨依达拉奉对6-羟基多巴胺(6-OHDA)诱导的帕金森病(PD)大鼠模型的神经保护作用及其作用机制。方法用6-OHDA制备SD大鼠PD模型,观察依达拉奉对PD模型大鼠行为学改变、酪氨酸羟化酶(TH)阳性细胞数和超氧化物歧化酶(SOD)、羟自由基(.OH)的影响。结果依达拉奉呈剂量依赖性减少阿朴吗啡(APO)诱发的大鼠PD模型旋转次数(P<0.01);依达拉奉(3mg/kg×14d,×28d)可阻止模型大鼠TH阳性细胞的减少,增加大鼠黑质纹状体SOD含量(P<0.05),降低.OH含量。结论依达拉奉增加大鼠黑质纹状体SOD含量,降低.OH含量,对6-OHDA诱导的PD动物模型具有神经保护作用。
Objective To investigate the neuroprotective effects of edaravone on 6-OHDA-induced dopaminergic neurons of the substantia nigra （SN） and underlying mechanism in rat model with Parkinson＇s disease（PD）. Methods The PD model was induced by injecting 6-OHDA into left medial forebrain bundle. The effects of edaravone on the behavior of rats, the number of positive cells of tyrosine hydroxylase（TH） and the contents of superoxide dismutase（ SOD） and · OH in the SN were observed. Results Edaravone（3 mg/kg, X 14 d, × 28 d） dose-dependently decreased the rotation behavior of rat models induced by apomorphine （P〈0. 01）, ameliorated the spontaneous behavior, prevented the decrease in the number of SN TH-positive cells induced by 6-OHDA （P〈0. 05）, increased the content of SOD,and decreased the content of OH in the SN. Conclusion Edaravone has neur0protective effects on the 6-OHDA-induced PD rat model by increasing the Content of SOD and decreasing the content of OH in the dopaminergic neurons.
出处
《江苏医药》
CAS
北大核心
2013年第7期779-782,共4页
Jiangsu Medical Journal
关键词
帕金森病
依达拉奉
Parkinson＇s disease
Edaravone
