摘要
目的探讨保乳术在Ⅰ、Ⅱ期三阴性乳腺癌中的应用价值。方法回顾性分析2001年1月～2009年1月行保乳术治疗的108例乳腺癌患者的临床病理资料,三阴组40例,非三阴组68例,两组进行对比研究。同期收集行改良根治术的三阴性乳腺癌患者52例,与上述行保乳术的三阴性乳腺癌患者的预后进行对比研究。结果本组TNBC168例,占15.6%(168/1076),三阴组年龄≤40岁29例,占72.5%,肿瘤直径2～3cm者28例,占70%,以上指标与非三阴组比较,差异有统计学意义(P<0.05);所有患者随访3年,保乳术患者复发12例,转移6例,死亡8例,其中三阴组复发5例,转移3例,死亡6例,与非三阴组比较,复发率差异无统计学意义(P>0.05),远处转移率及3年生存率差异均有统计学意义(P<0.05);与改良根治组比较,复发率、远处转移率及3年生存率差异均无统计学意义(P>0.05)。结论 三阴性乳腺癌患者发病年龄较轻、肿瘤体积较大,行保乳术后复发率与非三阴组无差别,复发率、远处转移率及3年生存率与改良根治组均无差别,保乳术可以作为Ⅰ、Ⅱ期三阴性乳腺癌的手术选择。
Objective To analyze and discuss the application value of breast conservation surgery in triple - negative breast cancer （TNBC） stage I and II. Methods The clinical data of stage I and lI breast cancer patients underwent breast conservation surgery thera- py （40 cases in triple - negative group and 68 sases in non - triple - negative group） and breast modified radical mastectomy therapy （modified radical mastectomy group 52 cases） in our hospital, during a period from Jan 2001 to Jan 2009,was retrospectively analyzed. Now we compared the prognosis between the breast conservation surgery group（triple- negative group）and the modified radical mastecto- my group in this paper. Results Of the 1076 patients,15.6% （168/1076） was TNBC patients. In the TNBC patients,72.5% whose age was younger than forty years and 70% whose diameter was 2 - 3cm. The age and the tumor diameter were significantly greater in TNBC group than in non - TNBC group （P 〈0.05）. The follow - up was 3 years. Of all the cases,12 occurred local recurrence,6 distant metasta- sis and 8 died. It was 5,3 and 6 in triple - negative （TN） group. Compared with the non - triple - negative （NTN） group, the TN cases were more likely to occurring distant metastasis（P 〈0.05）. The 3 -year survival rate in TN group were significantly higher than in NTN group （ P 〈 0.05 ）. Compared with the modified radical mastectomy group, for the local recurrence rate, distant metastasis rate and 3 - year survival rate,there were no significant differences（P 〉 0.05 ）. Conclusion These patients of TNBC were usually young（ age 〈 40） , with tumor being large. There was no significant difference between TN and NTN in local recurrence rate,which under breast conservation sur- gery. There was no significant difference in local recurrence rate,distant metastasis rate and 3 - year survival rate between the breast con- servation group（TN） and the modified radical mastectomy group. So the breast conservation surgery treatment way
出处
《医学研究杂志》
2013年第3期38-40,共3页
Journal of Medical Research
基金
卫生部医药卫生科技项目(W2012FZ139)
关键词
三阴性乳腺癌
临床病理特征
保乳术
Triple- negative breast cancer
Clinicopathological characteristics
Breast conservation surgery
