摘要
目的:探讨雌激素受体(ER)和表皮生长因子受体(EGFR)在分化型甲状腺癌(DTC)中的表达及其意义。方法:用免疫组化SP法检测45例(DTC)组织中ER和EGFR的表达。结果:ER在DTC组中的阳性率为37.3%,明显高于良性腺瘤和正常组(P<0.05);EGFR在DTC组中的阳性率为57.7%,明显高于两对照组(P<0.05)。ER在DTC中的表达与性别和年龄有关;EGFR的表达与DTC中的淋巴结转移有关。结论:ER和EGFR的表达可以作为鉴别甲状腺肿瘤良恶性的指标EGFR可作为甲状腺癌患者预后的指标。
Objective： To investigate the expression and significance of estrogen receptor（ER） and epidermal growth factor receptor（EGFR） in the differentiated thyroid carcinoma（DTC）.Methods： The expression of ER and EGFR was detected in 45 cases of DTC with paraffin-embedded by S-P immunohistochemical technique.Results： The positive percentage of ER expression in DTC was 37.3 %,and it is significantly higher than that in thyroid adenoma and normal thyroid（P0.05）;The positive percentage of EGFR expression of was 57.7 % in DTC,and it is significantly higher than that in others（P0.05）.The expression of ER was associated with the gender and age,and the expression of EGFR was associated with lymph node metastasis.Conclusion： The expression of ER and EGFR may be served as markers in identifying thyroid cancer and thyroid innocuous node.EGFR positive expression is predictive of poor prognosis.
出处
《现代生物医学进展》
CAS
2013年第5期908-910,927,共4页
Progress in Modern Biomedicine
