摘要
目的探讨氟喹诺酮类药物诱发癫痫的相关危险因素,为临床安全用药提供依据。方法对收治的17例氟喹诺酮类药物所致癫痫发作,按照患者病情情况、药品种类、给药途径、不良反应的表现、转归等进行统计分析。结果氟喹诺酮类药物所致癫痫发作17例中年龄>60岁8例(占47.1%),既往有抽搐或癫痫史5例,患脑动脉硬化、脑梗塞者5例,肾功能不全3例;引起癫痫发作的氟喹诺酮为环丙沙星7例、左氧氟沙星5例、氟罗沙星3例、诺氟沙星1例、氧氟沙星1例,静脉给药共15例,口服2例;4例合用茶碱类药物,3例合用非甾体抗炎药。15例为大发作,2例为小发作,发作的开始时间在用药后30min～5d;17例患者均在停药或抗癫痫等对症治疗后好转出院。结论氟喹诺酮类药物可致癫痫发作,临床应高度重视,合理使用,以保障患者用药安全。
Objective To understand the causes of epilepsy induced by fluoroquinolones, and to improve the corresponding preventive measures. Methods The reported cases with epilepsy induced by fluoroquinolones from nanchong central hospital （2001.1～2011.9） were collected and analyzed. Results 17 patients with fluoroquinolones-induced epilepsy were collected. 8 cases were older than 60, 5 cases had a previous history of epilepsy, 3 cases of renal insufficiency, 5 cases accompanied with cerebral arteriosclerosis, cerebral infarction. Epileptic seizures caused by fluoroquinolone for 7 cases of ciprofloxacin, 5 cases of levofloxacin, 3 cases of Fleroxacin, 1 cases of norfloxacin, 1 cases of ofloxacin, among them, 15 cases were intravenous administration, infusion time was 15 to 40 minutes, 2 cases were oral administration. 4 patients were coadministered with theophylline-containing preparations, 3 cases were coadministered with non-steroidal anti-inflammatory drugs. Of the 17 patients, 15 cases were generalized tonic-clonic seizures, 2 cases were partial seizures. The time of onset of seizures was 30 min to 5 d after fluoroquinolones use. After drug withdrawal or systematic therapy, 17 patients had recovered and were discharged. Conclusion It was important for clinicians and pharmacists to know the predisposing factor of fluoroquinolone-induced epilepsy, and rational used it.
出处
《西部医学》
2013年第4期540-541,共2页
Medical Journal of West China
