摘要
目的探讨红花注射液联合胰激肽原酶治疗早期糖尿病肾病的疗效及对患者血清CRP、TNF-α及IL-6水平的影响。方法 60例糖尿病肾病患者,分为观察组和对照组,对照组采用卡托普利治疗;观察组采用红花注射液联合胰激肽原酶治疗。结果治疗后观察组总有效率83.33%,高于对照组总有效率的53.33%,差异有统计学意义(P<0.05);观察组24 h尿蛋白定量及Scr改善情况优于对照组,差异有统计学意义(P<0.01)。治疗后,观察组患者的UAER改善情况优于对照组,差异有统计学意义(P<0.01)。结论红花注射液联合胰激肽原酶治疗早期糖尿病肾病疗效可靠。红花注射液联合胰激肽原酶治疗糖尿病肾病患者的机制可能在于微炎症状态的改善减轻了血管内皮损伤,从而延缓糖尿病肾病进展。红花注射液联合胰激肽原酶可以改善早期糖尿病肾病患者的血清CRP、TNF-α及IL-6水平。
Objective To study the effect of safflower injection combined with pancreatic kininogenase in treatment of early diabetic nephropathy and the intervention of serum CRP,TNF-α and IL-6 levels in patients. Methods A total of 60 cases of diabetic nephrosis patients divided into the observation group and the control group. The control group：the use of captopril. The observation group：the use of safflower injection combined with pancreatic kininogenase. Results After treatment,the total efficiency in the observation group was 83.33% higher than 53.33% in the control group, there were significant differences （P 〈 0.05 ）. After treatment ,24 h urine protein and Scr improved the situation of the patients in the observation group was better than the control group,there were significant differences（P 〈 0.01 ）. After treatment,the improvement of UAER patients in the observation group better than the control group,there were signif- icant differences （P 〈 0.01 ）. Conclusion Safflower injection combined with pancreatic kininogenase in treatment of early diabetic nephropathy,the curative effect was reliable. Safflower injection combined with pancreatic kininogenase in treatment of patients with diabetic nephropathy mechanisms,may be the micro inflammatory state in improving vas- cular endothelial injury loss, thereby slowing the progression of diabetic nephropathy. Safflower injection combined with pancreatic kininogenase can improve serum CRP,TNF-α and IL-6 levels in patients with early diabetic nephropathy.
出处
《中国现代医生》
2013年第7期70-72,共3页
China Modern Doctor
基金
浙江省医药卫生科技计划(2005A093)
