摘要
以二茂铁硫代甲酸和二正丁基氧化锡反应 ,合成了未见文献报道的二正丁基锡新型配合物 (n -Bu) 2 Sn (FcCOS) 2 [Fc=(η5-C5H5)Fe (η5-C5H4 ) ]。通过元素分析、红外光谱和核磁共振 (1H、13 C、119 Sn)谱等有关数据对配合物的组成和结构进行了表征 ,并推测出配合物可能的分子结构。测定了配合物的体外抗癌活性。结果表明 ,配合物对人白血病HL - 6 0、人结肠癌HCT - 8、人胃癌BGC - 82 3和人鼻咽癌KB等癌细胞均有很好的抑制能力。
By the reaction of (n-Bu) 2SnO with FcCOSH(Fc=Ferrocenyl), the novel complex(n-Bu) 2Sn(FcCOS) 2 has been synthesized The composition and structure of the novel complex has been characterized by elemental analysis, IR and NMR ( 1H, 13 C and 119 Sn) spectroscopy, and its possible molecular structure has been suggested The antitumour activity of the novel complex has been tested in vitro The result shows that (n-Bu) 2Sn(FcCOS) 2 exhibit better antitumour activity in vitro against HL-60、HCT-8、BGC-823、KB tumour cells
关键词
二茂铁硫代甲酸
抗癌活性
二正丁基锡配合物
diorganoltin complex
ferrocenylthiocarboxylic acid
synthesis
spectroscopic characterization
antitumour activity
