摘要
目的探讨三维适形放射治疗(3DCRT)同步奥利沙铂(L-OHP)化疗治疗晚期局限性非小细胞肺癌(NSCLC)的临床疗效。方法将入选的90例局限性NSCLC患者随机单盲分为A组(47例)和B组(43例),B组患者给予3DCRT放射治疗方案,A组患者在此基础上同步给予L-OHP化疗,对比两组患者治疗后临床疗效和不良反应。结果 (1)A组患者完全缓解率(10.6%)和总有效率(78.7%)均高于B组患者(7.0%和55.8%,P<0.05);(2)A组患者治疗后生活质量改善情况优于B组患者(Z=-2.155,P=0.031);(3)A组患者骨髓抑制、胃肠道反应、末梢神经损害和放射性肺损伤发生率高于B组患者(P<0.05)。结论 3DCRT放射治疗同步L-OHP化疗能提高NSCLC患者病灶的近期控制率,但应做好对联合放化疗期间出现不良反应的对症处置。
Objective To explore the clinical effect of dimensional conformal radiotherapy（3DCRT） combined with concurrent Oxaliplatin（L-OHP） in treatment of patients with limited advanced non-small cell lung cancer（NSCLC）.Methods 90 admitted patients were randomly divided into A group（47 cases）and B group（43 cases）,B group was treated with 3DCRT regime,based on which A group was applied L-OHP therapy,and clinical efficacy,toxic side reactions were compared between two groups.Results（1）Complete remission rate total efficiency rate of A group were higher than those of B group（P0.05）;（2）Obvious improvement of quality of life of A group was superior to B group（Z=-2.155P=0.031）;（3）During treatment,incidence rate of myelosuppression,gastrointestinal tract reaction,peripheral nerve damage,radiation induced lung injury in Agroup was higher than that of B group（P0.05）.Conclusions 3DCRT radiotherapy combined with concurrent L-OHP chemotherapy in treatment of limited advanced NSCLC can improve control rate of primary lesion,but attention also should be paid to symptomatic disposal for toxicity reactions.
出处
《中国肿瘤临床与康复》
2013年第3期232-234,共3页
Chinese Journal of Clinical Oncology and Rehabilitation
关键词
三维适形放疗
奥利沙铂
疗效
不良反应
Three dimensional conformal radiotherapy
Oxaliplatin
Efficacy
Adverse reactions
