摘要
目的观察帕瑞昔布钠预防全麻下甲状腺次全切手术术后躁动的有效性和安全性。方法择期行甲状腺次全切除术患者60例,美国麻醉医师协会分级(ASA)Ⅰ～Ⅱ级,随机分为两组,均采用七氟醚全麻,帕瑞昔布钠组(P组,n=30),于插管后立即静脉推注帕瑞昔布钠40 mg;对照组(C组,n=30),于插管后静脉推注生理盐水2 mL。观察两组患者拔管期间躁动发生率、躁动程度0～3级评分,术后随访记录患者术后1、2、4、6、12、24 h的视觉模拟评分(VAS);以及术后24 h内患者恶心呕吐、呼吸抑制、出血等发生情况。采用SPSS 13.0软件进行统计学分析,数据比较采用t检验和χ2检验。结果拔管期P组1级以上躁动发生率显著低于C组(P<0.05);P组VAS评分在1、2、4、6、12 h均低于C组(P<0.05)。结论帕瑞昔布钠超前镇痛用于全麻下的甲状腺手术,可显著减少术后燥动,且能有效减轻术后疼痛。
Objective To investigate the preventive effect and safety of Parecoxib on preventing postoperative agitation after thyroid operation with general anesthesia. Methods 60 patients of ASA I～Ⅱ, scheduled for subtotal thyroidectomy, were randomly divided into two groups, and all patients were received Sevoflurane general anesthesia： Parecoxib Sodium group （group P, n = 30）, 40 mg Parecoxib Sodium was injected through vein after endotraeheal intubation; control group （group C, n = 30）, 2 mL normal saline was injected through vein after endotracheal intubation. The drawing tube restless incidence and restless degree score were observed. Postoperative VAS scores which assessed 1, 2, 4, 6, 12, 24 h after operation were collected. The data whether appeared nausea and vomiting, respiratory depression and haemorrhage in 24 h after operation were recorded. Statistical analysis was performed by SPSS 13.0 software, t-test and X^2 test were used to compare the data. Results Compared with group C, above one level restless incidence of tracheal extubation period of group P was lower （P 〈 0.05）, and VAS scores of 1, 2, 4, 6, 12 h were lower neither （P 〈 0.05）. Conclusion Preproccessing Parecoxib Sodium for general anesthesia of thyroid surgery, can significantly reduce postoperative dryness dynamic, and can effectively reduce postoperative pain.
出处
《中国医药导报》
CAS
2013年第10期95-96,103,共3页
China Medical Herald
关键词
帕瑞昔布钠
超前镇痛
术后躁动
甲状腺手术
Parecoxib Sodium
Preemptive analgesia
Postoperative agitation
Thyroid operation
