摘要
以对乙酰氨基酚为模型药物 ,采用甲醛蒸汽交联明胶胶囊的方法制备了胃内滞留型控释胶囊。该胶囊在人工胃液中的释药曲线符合零级动力学模型。家兔在体试验表明 ,本品的胃内滞留时间在 6 h以上。
A laboratory method of preparing controlled release capsules floated in artificial gastric juice was developed by crosslinking the gelatin capsules with formaldehyde vapor. The release of taracetamol from the crosslinked gelatin capsules over time accorded with zero kinetic models in the artificial gastric juice. The residence time of the controlled release capsules was more than 6 h in rabbit stomach. \;
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
2000年第9期397-399,共3页
Chinese Journal of Pharmaceuticals
关键词
胃内滞留型控释胶囊
对乙酰氨基酚
甲醛
floating capsules
controlled release capsule
paracetamol
formaldehyde
