摘要
目的:探讨帕罗西汀联合小剂量多塞平治疗老年期抑郁症的疗效及安全性。方法:将60例老年期抑郁症患者随机分为研究组(帕罗西汀联合小剂量多塞平组)与对照组(帕罗西汀组)各30例,分别予帕罗西汀联合小剂量多塞平与帕罗西汀药物治疗,疗程均为8周。临床疗效评定分别采用汉密尔顿焦虑量表(HAMA)、汉密尔顿抑郁量表(HAMD-17)、临床疗效总评量表-病情严重度(CGI-SI)、治疗中出现的症状量表(TESS)于治疗前后进行评定。结果:研究组在治疗第2、4、6、8周末HAMA总分下降快于对照组,差异有统计学意义(P<0.05);在治疗第2、4周末HAMA减分率均高于对照组,差异均有统计学意义(P<0.05)。研究组在治疗第8周末HAMD总分下降显著快于对照组,差异有统计学意义(P<0.05);研究组在治疗第2、8周末HAMD减分率高于对照组,差异有统计学意义(P<0.05或P<0.01)。在治疗第8周末研究组总有效率为80.00%与对照组的70.00%差异无统计学意义(P>0.05)。研究组的显效率为50.00%与对照组的28.13%差异有统计学意义(P<0.05)。研究组不良反应发生率为50.00%高于对照组的23.33%,但差异无统计学意义(P>0.05)。结论:帕罗西汀联合小剂量多塞平治疗老年期抑郁症的疗效优于单用帕罗西汀组,无明显不良反应。
Objective： To explore the clinical curative effects and safety of Paroxetine combined with a small amount of Doxepin in the treatment of old age depression. Methods ：60 patients with of old age depression were randomly divided into study group （Paroxetine combined with a small amount of Doxepin group） and the control group （ Paroxetine group） 30 cases each, Respectively, Taking Paroxetine combined with a small amount of Doxepin and Paroxetine treatment lasted 8 weeks. Clinical efficacies were assessed with the Hamilton anxiety scale（ HAMA）, the Hamilton Depression Scale （HAMD） and the Clinical Global Impression Severity of Illness（ CGI - SI） and adverse reactions with the Treatment Emergent Symptom Scale （TESS） before treatment and after treatment. Results： The study group in the treatment of 2,4,6,8 weekend HAMA total score falls faster than the control group, the difference was statistically significant （ P 〈 0.05 ）, Study Group HAMA the less points rate higher than that of the control group were statistically significant differences （ P 〈 0.05 ） in the treatment of the first 2,4 weekend. Study Group 8 weeks of treatment HAMD total score decreased significantly faster than the control group difference was statistically significant （P 〈 0.05）. Study Group in the treatment of the first 2,8 weekend HAMD reduction rate higher than that of the control group difference was statistically significant （ P 〈 0.05 or P 〈 0.01 ）. The study group after 8 weeks of treatment the total effective rate was 80.00%, and 70.00% of the control group, the difference was not statistically significant （P 〉 0.05 ）. The remarkable efficiency of the study group was 50, 00% and 28.13% of the control group, the difference was statistically significant （P 〈 0.05 ）. The adverse reaction rate was 50.00% higher than the 23.33%, but the difference was not statistically significant （ P 〉 0.05）. Conclusions： More effective than Paroxetine combined with a small amount of Do
出处
《中国民康医学》
2013年第5期29-32,共4页
Medical Journal of Chinese People’s Health
