摘要
[目的]比较磁共振成像(MRI)和18F-氟代脱氧葡萄糖—正电子发射计算机体层摄影(PET-CT)对放疗后鼻咽癌颅底复发的诊断价值。[方法]48例放疗后的鼻咽癌患者,均行鼻咽MRI和PET-CT显像。比较MRI和PET-CT诊断放疗后鼻咽癌颅底复发的灵敏度、特异性、准确率、阳性预测值及阴性预测值。[结果]PET-CT和MRI对颅底复发诊断的灵敏度、特异性、准确率、阳性预测值和阴性预测值分别为94.1%和88.2%、42.9%和35.7%、79.2%和72.9%、80.0%和76.9%、75.0%和55.6%。PET-CT和MRI联合时灵敏度、特异性、阳性预测值、阴性预测值和准确率分别为93.8%、31.3%、73.2%、71.4%和72.9%,与MRI和PET-CT比较,差异均无统计学意义(P>0.05)。颅底有软组织者复发组占85.3%,未复发组仅占28.6%,差异有统计学意义(P<0.05)。复发组标准化摄取值(SUV)平均为7.59(1.9~15.4),未复发组SUV为3.86(0.7~8.4),差异有统计学意义(P=0.000)。[结论]PET-CT和MRI在鼻咽癌放疗后疑似颅底复发诊断上无明显差异,两者联合亦未显示优势。
[Purpose] To compare the value of positron emission tomography(PET) using 18-fluoro-2-deoxyglucose(FDG) with magnetic resonance imaging(MRI) in nasopharyngeal carcinoma(NPC) post-radiation with skull base recurrence.[Methods] The imaging of MRI and PET-CT scans of 48 post-radiation NPC patients were reviewed.The sensitivity,specificity,accuracy,positive predictive value(PPV) and negative predictive value(NPV) of MRI and PET-CT were calculated and analyzed.[Results] For detecting skull base recurrence of post-radiation NPC,the sensitivity of PET-CT and MRI were 94.1% and 88.2%,respectively;specificity,42.9% and 35.7%;accuracy,79.2% and 72.9%;PPV,80.0% and 76.9% ;NPV,75.0% and 55.6%,respectively.When combined detection of PET-CT and MRI,the sensitivity,specificity,PPV,NPV and accuracy were 93.8%,31.3%,73.2%,71.4% and 72.9%,respectively,without significant difference compared with PET-CT or MRI alone(P0.05).Soft-tissue mass was found in 85.3%(29 of 34)of recurrent patients,and in 28.6%(4 of 14)of non-recurrent patients,with significant difference between them(P0.05).The average standard uptaken value(SUV) was 7.59(range 1.9~15.4) in the recurrent group,while 3.86(range 0.7~8.4)in the non-recurrent group,with significant difference(P=0.000).[Conclusion] In patients suspicious of recurrence in the skull base after radiotherapy in NPC,there is no significant difference in the diagnostic value between PET-CT and MRI,neither is combined detection of PET-CT and MRI.
出处
《肿瘤学杂志》
CAS
2013年第3期175-178,共4页
Journal of Chinese Oncology
关键词
放射疗法
鼻咽肿瘤
磁共振成像
体层摄影术
发射型计算机
颅底
复发
radiotherapy
nasopharyngeal neoplasms
magnetic resonance imaging
tomography
emission computed
skull base
recurrence