摘要
目的观察冠状动脉内注射半剂量替罗非班对老年ST段抬高心肌梗死(STEMI)接受急诊PCI患者术中慢血流的有效性及安全性。方法选择因STEMI住院行急诊PCI术,并于术中出现慢血流患者共217例,根据冠状动脉内应用替罗非班的剂量分为半剂量组(5μg/kg)126例和常规剂量组(10μg/kg)91例,比较2组一般临床特点,分析有效性及安全性。结果半剂量组轻度出血比例明显低于常规剂量组(1.6%vs 7.7%,P<0.05)。而2组患者LVEF、ST段回落、中度出血及院内病死率比较差异无统计学意义(P>0.05)。结论针对老年STEMI患者的临床特点,急诊PCI过程中出现慢血流时选择冠状动脉内应用半剂量替罗非班安全、有效。
Objective To study the safety and effect of 50% tirofiban dose on slow flow in elderly patients with acute myocardial infarction（AMI） during emergency percutaneous coronary intervention（PCI）. Methods Two hundred and seventeen AMI patients with slow flow during emergency PCI for ST-segment elevation were divided into 50% tirofiban dose （5μg/kg） group （n ： 126） and routine tirofiban dose（10μg/kg） group. Their clinical features and the safety and effect of tirofiban were compared and analyzed. Results The incidence of mild bleeding was significantly lower in 50%tirofiban dose group than in routine tirofiban dose group（1.6% vs 7.7% ,P〈0. 05）. No significant difference was found in the LVEF, ST-segment resolution, moderate bleeding and in hospital death rate between the two groups（P〉0.05）. Conclusion Intracoronary 50% tirofiban dose is safe and effective for slow flow in elderly AMI patients during emergency PCI.
出处
《中华老年心脑血管病杂志》
CAS
北大核心
2013年第4期346-348,共3页
Chinese Journal of Geriatric Heart,Brain and Vessel Diseases
基金
首都医科大学基础临床科研项目(10JL53)
关键词
心肌梗死
支架
血流速度
阿司匹林
血小板聚集抑制剂
替罗非班
myocardial infarction
stents
blood flow velocity
aspirin
platelet aggregation inhibitors
tirofiban
