摘要
系统性红斑狼疮(systemic lupus erythematosus,SLE)是一种由遗传、环境、免疫等多种因素参与引起的多器官、多系统损害的自身免疫性疾病,其发病机制复杂,临床表现多样,病情多呈进行性发展。对于SLE的治疗,传统上主要以糖皮质激素联合免疫抑制剂为主,严重者辅以细胞毒药物或生物调节剂,但总体疗效欠佳,且不良反应较大。近年来,大量的基础研究和临床试验表明,免疫因素在SLE发病机制中起主要作用,三氧化二砷(ATO)能有效缓解、控制SLE的症状,并且对ATO治疗SLE的作用机制也进行了许多深入的研究。该文拟从ATO的药效特性、临床应用、作用机制等方面对ATO治疗SLE的研究现况做一概述。
As an autoimmune disease, systemic lupus erythematosus is caused by genetics, environment, immune factors, etc, which results in multi-organs and multi-system＇s damage. It has complex pathogenesis, diverse clinical manifestations and the progress conditions ongoing deteriorated. Traditionally, combining glucocorticoid with immunosuppressant is the main treatment for systemic lupus erythematosus, while cytotoxic drugs or biological modifiers are supplemented for severe patients, but the result is not satisfactory, and these drugs often lead to tremendous side effects. In recent years, a large number of basic and clinical trials in domestic and abroad indicate that immune factors play a important role in the pathogenesis of SLE. Arsenic trioxide （ATO） can effectively alleviate and control the symptoms of SLE, what＇s more, many in-depth research have attempted to figure out the mechanism of ATO to the treatment of SLE. This review intends to make a brief introduction of pharmacodynamic characteristics of ATO as well as its clinical application, and mechanism of ATO in the treatment of SLE.
出处
《实用皮肤病学杂志》
2013年第2期99-101,共3页
Journal of Practical Dermatology
