摘要
目的探讨体外受精-胚胎移植(IVF-ET)周期中,影响胚胎着床的原因,为单胚胎移植,减少多胎妊娠寻找理论依据。方法 IVF-ET 1,193个周期,根据胚胎种植率分为三组:A组种植率0%;B组种植率50%;C组种植率100%。将三组的胚胎形态及临床各参数比较分析。结果 1,193个周期鲜胚移植共984个周期,三组注射人绒毛膜促性腺激素(HCG)日血清黄体生成素(LH)、雌二醇(E_2)水平、子宫内膜厚度有差异,但无统计学意义(P>0.05);三组HCG日血清孕酮(P)水平分别为(2.69±1.00)nmol/L、(2.64±0.97)nmol/L、(2.51±0.94)nmol/L,其中A与C组差异有统计学意义(P<0.05)。三组移植胚胎形态也存在明显的差异,D3的8A级胚胎的比率分别为31.53%、50.53%、60.20%。A组中,D3的6细胞和少于6细胞的移植胚胎率明显显著高于另外两组(P<0.01)。结论在注射HCG日血清P水平较低,胚胎8A的比率较高,年龄较轻的患者,其胚胎的着床率较高,是进行单胚胎移植的适宜人群。
Objective： To analyze the influence factors of embryo implantation in vitro fertilization-embryo transfer（IVF-ET）. Methods： Nine hundred and eighty-four cycles of infertile patients who underwent IVF-ET in Zhuhai Maternal and Children＇s Hospital and Health Institute from January 2011 to December 2011 were analyzed retrospectively. The patients were divided into three groups：group A （implantation rate 0%, n = 344）, group B（implantation rate 50%,n=285）and group C（implantation rate 100% ,n=255）. The difference of embryo morphology and clinical variables were compared and analyzed among the three groups. Results： No statistically significant difference was found in the levels of luteinizing hormone（LH）and estradiol（E2）in serum,and endometrial thickness on HCG day among three groups（P〉0.05）. The levels of progesterone（P） on HCO day in group A, B, C were （2.69 ± 1.00） nmol/L, （2.64± 0.97） nmol/L, （2.51＋0.94）nmol/L in serum respectively. The difference between group A and group C was statistically significant（P〈0.05）. The embryos rates of grade 8A in group A,B and C were 31.53%, 50. 53% and 60.20% respectively. The difference was statistically significant among the three groups（P〈0.01）. The embryos rate of 6-cell and less than 6-cell in group A was signifieantly higher than the other two groups （P〈0.01）. Conclusions： The implantation rate is higher when the serum P value on HCG day is lower,the rate of embryos with grade 8A is higher,and the age is lower. Sueh kind patients are suitable for single embryotransfer.
出处
《生殖医学杂志》
CAS
2013年第3期190-193,共4页
Journal of Reproductive Medicine
关键词
种植率
胚胎移植
胚胎评分
孕酮
单胚移植
Implantation rate
Embryo transfer
Embryo morphology
Progesterone
Singleembryo transfer
