摘要
以1,3-环己二酮为原料,依次经亚胺化反应、Michael加成-环化反应、烷基化反应合成了含有端基炔的喹啉酮衍生物——1-(2-炔丙基)-7,8-二氢喹啉-2,5(1H,6H)-二酮,其结构经1H NMR,HR-MS和2D NMR确证。
1-（Prop-2-yn-l-yl） -7,8-dihydroquinoline-2,5 （ 1H, 6H）-dione （ 4 ） was simply prepared from 1,3-cyelohexadione by a three-step reaction of imidization, Michael reaction-intermolecular cy- cIization and alkylation. Two configuration stereo-isomers of 4 were isolated by chemical technology. The structures were confirmed by 1H NMR, HR-MS and 2D NMR.
出处
《合成化学》
CAS
CSCD
北大核心
2013年第2期170-173,共4页
Chinese Journal of Synthetic Chemistry
关键词
喹啉酮
端基炔
微波
合成
quinolinone
terminal alkyne
microwave
synthesis
