摘要
目的观察氢氯吡格雷联合冠心舒通胶囊对急性冠脉综合征患者经皮冠状动脉介入治疗(PCI)术后心绞痛的疗效,及对血清高敏C反应蛋白(hs-CRP)和低密度脂蛋白胆固醇(LDL-C)的影响。方法选择70例ACS行PCI术后患者心绞痛随机分为2组:对照组给予阿司匹林、硝酸酯类、β-受体阻滞剂、钙离子拮抗剂、他汀类药物、低分子肝素等,联合组在此基础上加用硫酸氢氯吡格雷和冠心舒通胶囊。2组治疗均为4周,分别在用药前及用药后14 d、30 d检测hs-CRP和LDL-C;在用药前后检测血尿常规、凝血酶原时间(PT)、APTT、血小板计数(PLT)、肝肾功能、血糖、血脂及心肌酶等测定。观察心血管事件的发生情况、药物不良反应、患者临床症状改善情况及hs-CRP、LDL-C水平。结果治疗后联合组和对照组的总有效率分别为94.29%和77.14%,联合组明显优于对照组(P<0.01)。2组患者hs-CRP水平较治疗前明显下降,联合组更为明显(P<0.05)。2组治疗后低密度脂蛋白胆固醇(LDL-C)水平较治疗前有下降(P<0.05)。其中LDL-C 2组治疗后比较,联合组较对照组下降更明显(P<0.05)。联合组在用药过程中未见明显不良反应。结论采用联合组的方法能显著改善冠心病PCI术后心绞痛的临床症状,并显著抑制炎性因子水平,降低hs-CRP、LDL-C,稳定斑块,降低心血管事件,且不增加出血事件的发生率,是一种辅助治疗急性冠脉综合征PCI术后心绞痛的安全有效的方法。
Objective To observe the effect of clopidogrel combined with Guanxin Shutong capsule on angina pectoris after percutaneous coronary intervention（PCI） for acute coronary syndromes（ACS）and its influence on the high sensitive C reactive protein（HS-CRP） and low density lipoprotein cholesterol（LDL-C）.Methods 70 cases of ACS patients with angina pectoris after PCI were randomly divided into 2 groups.The control group were treated with aspirin,nitrates,beta blockers,statins,and low molecular heparin.The united group based the treatment on the use of clopidogrel combined with Guanxin Shutong capsule.The course of treatment was 4 weeks.HS-CRP and LDL-C were detected 14d and 30d before and after the treatment respectively.Blood and urine routines,PT,APTT,and liver and kidney functions were tested before and after the meditation.All the patients were observed in terms of symptoms,cardiovascular events,adverse reactions,HS-CRP and LDL-C level.Results The total treatment efficacy for the united group and the control group was 94.29% and 77.14% respectively,the former significantly better than the latter（P〈0.01）.After the treatment,HS-CRP and LDL-C in the united group reduced more obviously than in the control group（P〈0.05）.There were no obvious adverse reactions in the two groups.Conclusion The united method can improve patients＇ clinical symptoms of angina pectoris after PCI,reduce the HS-CRP and LDL-C levels,and increase no chance of bleeding.It is a safe and effective method for the assistant treatment of angina pectoris after PCI.
出处
《淮海医药》
CAS
2013年第2期107-109,共3页
Journal of Huaihai Medicine
关键词
心绞痛
氢氯吡格雷
冠心舒通胶囊
LDL-C
高敏C反应蛋白
Angina pectoris
Clopidogrel
Guanxin Shutong capsule
Hypersensitive C reactive protein
Low density lipoprotein cholesterol
