摘要
原发性胆汁性肝硬化（PBC）是一种慢性进展性自身免疫性肝病，目前认为其发生机制主要是由于机体免疫系统对位于胆管上皮细胞线粒体上的自身抗原发生异常的免疫应答，从而引起免疫介导的胆管损伤和汇管区炎症。抗线粒体抗体阳性、血清IgM水平升高和汇管区淋巴细胞浸润是其主要的免疫学特征，而对IgM与PBC的基础和临床研究是阐明其异常免疫应答机制的一个重要途径。现将PBC患者高IgM水平的发生机制以及IgM在PBC中的免疫学作用及其临床应用概述如下，以IgM为切人点的研究也将有助于PBc的诊断和治疗。中华检验医学杂志，2013，36：201-205）
Primary biliary cirrhosis （PBC） is a slowly progressive autoimmune disease of the liver. Studies on the pathphysiology of this disease have demonstrated the immune-mediated destruction of the intrahepatic bile ducts and portal inflammation seem to be the result of an intense autoimmune response directed against the autoantigens located in the biliary epithelium. Immunologically, PBC is characterized by the presense of antimitochodrial antibodies, elevated serum IgM and lymphoid infiltration in the portal tract. Indeed, the relationships between IgM and PBC have been a major focus of research on its pathphysiology, which lead to an increased understanding of the abnormal immune responses involved in PBC. This review summarizes data on the biological and clinical significance of Hyper-IgM in PBC, and highlights the potential role of IgM for the diagnosis and treatment of PBC. （Chin J Lab Med, 2013,36：201-205）
出处
《中华检验医学杂志》
CAS
CSCD
北大核心
2013年第3期201-205,共5页
Chinese Journal of Laboratory Medicine
