摘要
为研究中草药对兴奋剂成瘾动物的戒断作用,研发无毒副作用和具有戒断作用的中药制剂,对120只仔鼠分别用递增剂量腹腔连续注射麻黄素溶液(2.0,3.0,4.0g.L-1)以及生理盐水,建立麻黄素成瘾动物模型,再分别用生理盐水和中药复方对其灌胃进行戒断.分别于灌胃5d,10d和15d时称量检测小鼠体重和大脑重量的变化,用生物显微镜观察分析小鼠大脑额叶皮层结构的变化.结果表明,实验对照组小鼠体重和大脑重量均低于正常对照组,中药组小鼠高于实验对照组,低于正常对照组;实验对照组小鼠额叶皮层厚度较正常对照组明显减小,中药组有所加厚;实验对照组小鼠额叶皮层组织结构有不同程度的损伤,细胞数目减少、分层不清晰、形态结构发生改变,中药组小鼠额叶皮层组织结构有所恢复.
To research the effect of Chinese medicine for ephedrine addiction animal, and to develop no side effects Chinese herba preparation for addiction effect, 120 filial mice are intraperitoneally injected with escalation doses （2.0,3.0,4.0g·L-1） of ephedrine or the same amount of saline to establish ephedrine addiction animal modle, then are given a gavage of saline or Chinese medicine for withdrawal respectively. The samples are collected at 5, 10 and 15 d, the body weight and the brain weight are measured, in addition, the changes of frontal lobe structure are observed by optical microscopy. Results show that the body weight and the brain weight of mice in the experimental control group are both lower than that in the natural control group in 5, 10 and 15 d after injecting ephedrine, while that of the Chinese medicine group is higher than the experimental control group. The thickness of mice frontal lobe of the experimental control group is thinner than that of the the natural control group, that of the Chinese medicine group is thicker than the experimental control group. The structure of mice frontal lobe is damaged in varying degree： cell migration, number reducing, stratification not clear, shape changing, the situation is improved in the Chinese medicine group.
出处
《西北师范大学学报（自然科学版）》
CAS
北大核心
2013年第2期84-89,共6页
Journal of Northwest Normal University(Natural Science)
基金
甘肃省自然科学基金计划项目(1107RJZA141)
兰州市社会发展项目(2010-127)
关键词
麻黄素
小鼠
大脑额叶
中药复方
ephedrine
mice
frontal lobe
Chinese medicine
