摘要
目的:研究不同剂量布地奈德雾化吸入治疗老年支气管哮喘急性加重期的临床效果,以探求一种最有效的使用剂量。方法:临床入选支气管哮喘急性加重期老年患者200例,按照入院先后顺序编号,根据随机数字方法分成4组,每组50例,分别为布地奈德2000μg/d雾化吸入治疗(A组);布地奈德4000μg/d雾化吸入治疗(B组);布地奈德6000μg/d雾化吸入治疗(C组);泼尼松30mg/d口服治疗作为对照组(D组)。比较分析各组患者的相关临床指标。结果:各组治疗4h后的FEV1占预计值的百分比、PEF占预计值的百分比以及临床评分较治疗前明显改善,且均具有统计学差异(P<0.05)。而四组之间的临床评分、FEV1占预计值的百分比以及PEF占预计值的百分比治疗前后的差值均无统计学差异(P>0.05)。治疗7天和21天后,与A组相比较,B组、C组和D组的FEV1占预计值的百分比以及PEF占预计值的百分比的治疗前后差值明显增高(P<0.05);与B组相比较,C组和D组的FEV1占预计值的百分比以及PEF占预计值的百分比的治疗前后差值也明显增高(P<0.05)。结论:雾化吸入布地奈德可以改善患者的肺功能以及临床表现,增大布地奈德混悬液雾化吸入剂量在一定程度上可以提高其疗效,6000μg/d雾化吸入与口服泼尼松30mg/d的疗效相当。
Objective To investigate the effect of inhaled budesonide in acute exacerbations of bronchial asthma in older adults.Methods 200 cases with primary hypertension were selected and divided into four groups,budesonide inhalation 2000μg /d treatment group（n=50,A group）,budesonide inhalation 4000μg /d treatment group（n=50,B group）,budesonide inhalation 6000μg /d treatment group（n=50,C group）,prednisone 30mg/d treatment group（n=50,D group）After the treatment we compare the clinical data of the four groups.Results Within the 4 groups of patients with acute exacerbation of bronchial asthma,clinical assessment score were declined after the treatment,with statistical differences（P0.05）The value of FEV1 and PEF which reflect the function of tracts improved with statistical differences（P0.05）.There were similar improvements in clinical assessment score and lung function in the four groups at the time of 4 hours and the second day after treatment（P0.05）.7 days after the beginning of treatment similar improvements in clinical assessment score and lung function in the four groups,and the difference of the improvements in lung function between the group of BUD6000ug and pred was not significant,but these lung function parameters were well improved in the group of BUD6000μg（C）BUD4000μg（B）BUD2000μg（A）.Conclusion This study indicates that inhaled corticosteroids was an ideal method in the treatment of acute exacerbations of bronchial asthma,there were similar improvements in budesonide inhalation 6000μg /d and oral administration of prednisone 30mg/d.
出处
《内蒙古中医药》
2013年第8期81-83,共3页
Inner Mongolia Journal of Traditional Chinese Medicine
