摘要
目的:观察通腑逐瘀解毒法对肝硬化大鼠血浆内毒素及TNF-ɑ的影响,初步揭示中药治疗肝硬化内毒素血症作用机理。方法:采用CCl4-橄榄油溶液联合LPS皮下注射方法复制大鼠肝硬化内毒素血症模型。造模成功后分别给予中药汤剂及乳果糖治疗,测定大鼠血氨、血浆内毒素、TNF-α及NO水平,光镜下观察肝组织炎症变化。结果:治疗组指标较模型组均有不同程度下降,以中药高剂量组内毒素及TNF-α降低最为明显。结论:通腑逐瘀解毒法能改善肝硬化内毒素血症,减轻肝脏炎症及纤维化,对肝硬化具有治疗作用。
Objective：To observe the effects of Tongfu Zhuyu Jiedu method on the level of endotoxin and TNF-ɑ in blood of cirrhosis rats,willing to unveil its mechanism of antagonizing inestinal endotoxemia（IETM）.Methods：Taking the way of CCl_4-olive oil mixed liquid combined with LPS subcutaneous injection to establish the rat liver cirrhosis models of IETM,then treated them with Chinese medicine and lactulose respectively,finally,measuring the levels of blood ammonia,endotoxin,TNF-ɑ and NO in blood and observing the inflammatory changes on liver tissue by light microscope.Results：All indexes of the treatment group were descended than model group to varying degrees,and the levels of endotoxin and TNF-α in high dose group reduced most.Conclusion：Tongfu Zhuyu Jiedu method can improve intestinal endotoxemia of liver cirrhosis,decrease liver inflammatory and fibrosis,and it has therapeutic effect to liver cirrhosis.
出处
《四川中医》
2013年第3期43-45,共3页
Journal of Sichuan of Traditional Chinese Medicine
