摘要
目的探讨法舒地尔联合尼莫地平预防动脉瘤术后迟发性脑血管痉挛的疗效和不良反应。方法搜集我院2010～2012年间动脉瘤性蛛网膜下腔出血术后的患者,分为3组。治疗组为法舒地尔联合尼莫地平,对照1组为单用法舒地尔,对照2组为单用尼莫地平。连用14 d,观察3组迟发性脑血管痉挛的发生情况和不良反应。结果治疗组迟发性脑血管痉挛发生1例,对照1组发生3例,对照2组发生5例。3组间差异有统计学意义(P<0.05)。不良反应3组间比较差异无统计学意义(P>0.05)。结论法舒地尔联合尼莫地平预防动脉瘤术后迟发性脑血管痉挛的疗效优于单用法舒地尔和单用尼莫地平,安全性亦较高。
Objective To investigate the efficacy and adverse effects of fasudil combined of nimodipine on the prevention of delayed cerebral vasospasm in patients after aneurysm operation. Methods To collect patients after aneurysmal subarachnoid hemorrhage and under go aneurysm operation in our hospital between 2010 -2012 who were divided into three groups. In the treatment group patients were treated with fasudil combined of nimodipine, while in the control A group with fasudil singly and in the control B group with nimodipine singly. Symptomatic cerebral vasospasm occurrence and adverse reactions were observed in two weeks in the three groups. Results In the treatment group, symptomatic cerebral vasospasm occurred in 1 case while in the control A group, 3 cases occurred and in the control B group, 5 cases occurred. The difference was statistically significant （ P 〈 0. 05 ） among three groups. The adverse reactions was no significant difference （P 〉 0.05 ）. Conclusion The efficacy of fasudil combined of nimodipine is better fasudil and nimodipine singly and the safety is equivalent.
出处
《河南科技大学学报（医学版）》
2013年第1期20-22,共3页
Journal of Henan University of Science & Technology:Medical Science
