摘要
逆转录病毒结合位点-1（Evi-1）基因是首先在小鼠粒细胞白血病发现的逆转录病毒结合位点。在恶性血液系统病变及其他实体肿瘤中高表达，致肿瘤机制主要为通过抑制Smads而抑制转化生长因子-β（TGF-β）信号途径，调节细胞周期，促进血管生成，抑制C-Jun氮末端激酶（JNK）及激活转录因子激活蛋白-1（AP-1）等。
Ecotropic viral integration site-1 (Evi-1) gene is first identified as a binding site for retrovirus in murine myeloid leukemia.The human homologue with the murine in leukemia oncogene Evi-1 is about 91％ of nuclear sequence and 94％ of amino acid.Evi-1 gene is high expressed in myeloid malignancies and other tumors.The main tumorigenic mechanisms of Evi-1 gene include inhibiting TGF-β signal path by depressing Smad3,adjusting cell cycle,promoting angiogenesis,inhibiting JNK.activating AP-1,and so on.
出处
《国际肿瘤学杂志》
CAS
2013年第3期170-173,共4页
Journal of International Oncology
基金
甘肃卫生行业科研计划项目
