摘要
目的探讨成人获得性噬血细胞综合症(hemophagocytic syndrome,HPS)肝功能损害的临床特点。方法回顾性分析郑州大学附属肿瘤医院2010年3月-2012年8月收治的24例成人获得性嗜血细胞综合症合并肝功能损害的患者,了解肝功能损害的特点,以及肝功能损害与获得性HPS病因和预后之间的关系。结果获得性HPS患者肝功能损害的特点为乳酸脱氢酶(LDH)及门冬氨酸转氨酶(AST)升高、低蛋白血症、高脂血症和黄疸。肿瘤继发HPS组乳酸脱氢酶(LDH)水平明显高于非肿瘤继发HPS组(P<0.05)。门冬氨酸转氨酶(AST)增高、白蛋白(ALB)降低提示预后不良(P<0.05)。24例患者中12周内共死亡15例,占62.50%。结论肝功能损害是获得性HPS常见的器官功能损害,其肝功能损害程度可能与获得性HPS的病因和预后相关。
Objective To investigate the clinical features of acquired hemophagocytic syndrome（HPS） complicated with hepatic dysfunction. Methods Retrospective analysis of 24 cases of adult hemophagocytic syndrome with hepatic dys- function who received treatment in our hospital between March. 2010 and Aug. 2012. The characteristics of hepatic dys- function, the relationship between hepatic dysfunction and the cause, as well as prognosis of the acquired HPS were pre- lim inarily analysed. Results The characteristics of hepatic dysfunction in acquired HPS patients were hypoproteine- mia, hyperlipidemia, jaundice and increase of aspartate aminotransferase （AST） and lactate dehydrogenase （LDH） lev- els. The level of LDH in the malignancy associated hemophagocytic lymphohistioeytosis group were higher than that in non - malignancy associated hemophagocytic lymphohistiocytosis group （ P 〈 0. 05 ）. And the increase of AST levels or the reduce of albumin （ALB） indicated poor prognosis （ P 〈 0.05 ）. Conclusions Liver damage is a common organ functional disorder in patients with acquired HPS , which may be correlated to the cause and the prognosis of acquired HPS.
出处
《医药论坛杂志》
2013年第2期1-4,共4页
Journal of Medical Forum
关键词
肝功能损害
噬血细胞综合症
乳酸脱氢酶
门冬氨酸转氨酶
白蛋白
Hepatic dysfunction
Hemophagocytic syndrome
Lactate dehydrogenase
Aspartate aminotransferase
Albumin
