期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

抑郁障碍与早年慢性应激的研究进展 被引量：4

原文传递
导出
摘要 抑郁障碍是一种以显著而持久的情绪低落、兴趣减退、活动减少为主要临床特征，同时伴有多种躯体不适的一类常见的情感障碍。具有高患病率、高复发率、高自杀率等特点，严重损害患者的学习、生活、工作，并给患者本人、家庭以及社会带来沉重负担。截至目前，抑郁障碍的病因和发病机制尚未明确，流行病学调查和临床研究发现早年慢性应激是诱发抑郁障碍的主要风险因素之一，而且各类环境、社会、心理应激对抑郁的发生、发展及预后均起着重要作用。
作者 廖雪梅 李幼虹 苏允爱 司天梅
机构地区 北京大学精神卫生研究所
出处 《中华行为医学与脑科学杂志》 CAS CSCD 北大核心 2013年第2期182-184,共3页 Chinese Journal of Behavioral Medicine and Brain Science
基金 国家自然科学基金项目（81171284）
关键词 抑郁障碍 慢性应激 流行病学调查 情绪低落 临床特征 情感障碍 躯体不适 高复发率
分类号 R749.4 [医药卫生—神经病学与精神病学]
  • 相关文献

参考文献33

  • 1Hammen C. Stress and depression. Annu Rev Clin Psychol,2005,1 : 293 -319. 被引量：1
  • 2Kessler RC, Mclaughlin KA, Green JG, et al. Childhood adversities and adult psychopathology in the WHO World Mental Health Surveys. Br J Psychiatry,2010,197:378-385. 被引量：1
  • 3EC Nelson Lynskey MT, Heath AC, et al. A family study of adult twins with and without a history of childhood abuse : stability of retro- spective reports of maltreatment and associated family measures. Twin Res Hum Genet ,2010,13 : 121-130. 被引量：1
  • 4Springer KW, Sheridan J, Kuo D, et al. Long-term physical and mental health consequences of childhood physical abuse : results from a large population-based sample of men and women. Child Abuse Neglect, 2007,31:517-530. 被引量：1
  • 5Chapman DP, Whitfield CL, Felitti VJ,et al. Adverse childhood expe- riences and the risk of depressive disorders in adulthood. J Affect Dis- ord,2004,82:217-225. 被引量：1
  • 6Kalinichev M, Easterling KW, Plotsky PM, et al. Long-lasting changes in stress-induced corticosteronc response and anxiety-like behaviors as a consequence of neonatal maternal separation in Long-Evans rats. Pharmacol Biochem Behav ,2002,73 : 131-140. 被引量：1
  • 7Huot RL,Thrivikraman KV,Meaney MJ,et al. Development of adult ethanol preference and anxiety as a consequence of neonatal maternal separation in Long Evans rats and reversal with antidepressant treat- ment. Psyehopharmacology (Bed) ,2001,158:366-373. 被引量：1
  • 8Uhelski ML, Fuchs PN. Maternal separation stress leads to enhanced emotional responses to noxious stimuli in adult rats. Behav Brain Res, 2010,212:208-212. 被引量：1
  • 9Leventopoulos M, Russig H, Feldon J, et al. Early deprivation leads to long-term reductions in motivation for reward and 5-HT1 A binding and both effects are reversed by fluoxetine. Neuropharmacology,2009,56: 692-701. 被引量：1
  • 10Ruedi-Bettschen D, Pedersen EM, Feldon J, et al. Early deprivation under specific conditions leads to reduced interest in reward in adult- hood in Wistar rats. Behav Brain Res,2005 ,156 :297-310. 被引量：1

二级参考文献84

  • 1喻冬山.情感性精神障碍的生物化学改变[A].姚芳传主编.情感性精神障碍 第1版[C].湖南科学技术出版社,1998.53—104. 被引量：1
  • 2Reagan LP, Magarinos AM, McEwen BS, et al. Neurological change induced by stress in streptozotocin diabetic rats[J]. Ann NY Acad Aci, 1999, 893:126-37. 被引量：1
  • 3Chugan HT, Behen ME, Muzik O. Local brain functional activity following early deprivation: a study of postinstitutionalized Romanian orphans[J]. Neuroimag ,200114 : 1290-1301. 被引量：1
  • 4Cameron HA, McEwen BS,Gould E. Regulation of neurogenesis by excitatory input and NMDA receptor action the dentate gyrus[J]. J Neurosci, 1995,15:4687-4692. 被引量：1
  • 5Moghaddam B. Stress activation of glutamate neurotransmission in the prefrontal cortex: Implication for dopamine-associated psychiatric disorders[J]. Bio Psychiatry, 2002,51:775-787. 被引量：1
  • 6Goldbergf JL, Barres BA. The relationship between neuronal survival and regeneration[J]. Annu Rev Neurosci. 2000, 23:579-612. 被引量：1
  • 7Smith MA, M akino S, Kretnansky R, et al Stress alters the expression of brain-derived neurotrophic factor and neurotrophin-3 mRNAs in hippocampus[J]. J Neurosci, 1995, 15:1768-1777. 被引量：1
  • 8Nibuga M, Takahasli M, Rusell DS, et al. Chronic stress increases catalytic TrkB mRNA in rat hippocampus[J]. Neurosci Lett., 1999, 267:81-84. 被引量：1
  • 9Vaidya VA, Duman RS. Role of 5-HT receptor in down-regulation of BDNF by stress[J]. Neurosci Lett, 1999,287:1-4. 被引量：1
  • 10Duman RS, Malberg JE. Neural plasticity in pathophysiology and treatment of depression [ J ]. Am Coil Neuropsychopharmacol , 1998, 37:261. 被引量：1

共引文献69

同被引文献48

  • 1傅文青,姚树桥,于宏华,赵幸福,李茹,李英,张艳青.儿童期创伤问卷在中国高校大学生中应用的信效度研究[J].中国临床心理学杂志,2005,13(1):40-42. 被引量：191
  • 2王瑞见.住院森田疗法治疗33例精神分裂症患者人格特征分析[J].神经疾病与精神卫生,2005,5(6):439-440. 被引量：1
  • 3李鹤展,张亚林,吴建玲,杨世昌,李龙飞,周云飞,赵幸福.210例抑郁症患者儿童期受虐史调查及临床特征[J].临床心身疾病杂志,2006,12(3):167-168. 被引量：12
  • 4Moncrieff J, Kirsch I. Efficacy of antidepressants in adults [ J ]. BMJ, 2005,331 (7509) : 155-157. 被引量：1
  • 5Kovacs D, Gonda X, Petschner P, et al. Antidepressant treatment re- sponse is modulated by genetic and environmental factors and their in- teractions[ J]. Ann Gen Psychiatry,2014,13 : 17. 被引量：1
  • 6Bauer M, Whybrow PC, Angst J, et al.World federation of societies of biological psychiatry (WFSBP) guidelines for biological treatment of u- nipolar depressive disorders, Part 1 : acute and continuation treatment of major depressive disorder[ J ] .World J Biol Psychiatry, 2002,3 ( 1 ) : 5 -43. 被引量：1
  • 7Enoch MA, Hodgkinson CA,Yuan Q, et al.The influence of GABRA2, childhood trauma, and their interaction on alcohol, heroin, and cocaine dependence [ J ]. Biol Psychiatry, 2010,67 ( 1 ) : 20-27. 被引量：1
  • 8Sun N, Xu Y, Wang Y, et al. The combined effect of norepinephrine transporter gene and negative life events in major depression of Chi- nese Han population [ J ]. J Neural Transm, 2008, 115 (12) : 1681- 1686. 被引量：1
  • 9Friedman ES, Davis LL, Zisook S, et al. Baseline depression severity as a predictor of single and combination antidepressant treatment out- come:Results from the CO-MED trial [ J ]. Eur Neuropsychopharma- col,2012,22(3) :183-199. 被引量：1
  • 10Yoshida K, Takahashi H, Higuchi H, et al. Predietion of antidepres- sant response to milnacipran by norepinephrine transporter gene poly- morphisms [ J]. Am J Psychiatry,2004,161 (9) : 1575-1580. 被引量：1

引证文献4

二级引证文献19

中华行为医学与脑科学杂志
2013年 第2期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部