摘要
【目的】探讨高同型半胱氨酸（Hey）血症的脑梗死患者复发的相关因素。【方法】收集2011年1月至2012年7月在本院神经内科住院的120例高Hcy血症的急性缺血性脑卒中患者，经随访6个月无复发的为初发脑梗死（F组）100例；在脑内出现新的梗死病灶，并有相应的体征的为复发性脑梗死（R组）20例，测定其血清Hcy、血糖、甘油三脂（TG）、胆固醇（TC）、高密度脂蛋白胆固醇（HDL—C）、低密度脂蛋白胆固醇（I．DL—c）水平并对其结果进行比较分析。【结果】R组的同型半胱氨酸为（28．29±11．62）”mol／L，F组同型半胱氨酸为（21．10±9．23）p．mol／L，两组相比差异有显著性（P〈0。05）。F组与R组比较：Hcy、LDL-C明显降低，HDL-C明显升高，且差异有显著性（P〈0．05）。TG、TC两组相比较差异无显著性（P〉0．05）。高Hcy血症脑梗死R组患有高血压、糖尿病、冠心病者与F组相比差异无显著性（P〉0．05）。复发组伴有多种危险因素的比率显著高于初发组。【结论】除高血压、糖尿病、冠心病是脑梗死复发的传统危险因素外，对于伴有高Hcy血症的脑梗死的复发，Hcy是主要的危险因素。
[Objective]To explore the related factors of the recurrence of cerebral infarction patients with hyperhomocysteinaemia. [Methods] Totally 120 cases of acute stroke with hyperhomoeysteinaemia in neurolo- gy department of our hospital from January 2011 to July 2012 were collected. Incipient cerebral infarction group（group F） included 100 patients without recurrence after the 6 months of follow-up. Recurrent cerebral infarction group（group R） included 20 patients with new infarction lesions in the brain and the corresponding signs. Serum homocysteine（Hcy）, blood glucose, triglycerides（TG）, cholesterol（TC）, high density lipopro- tein cholesterol（HDL-C）, low density lipoprotein cholesterol（LDL-C） were measured and compared. IRe- suits] Hcy level in group R and group F was （28.29±11.62）umol/L and （21.10±9.23）umol/L respective- ly, and there was significant difference（ P d0.05） . Compared with group R, Hcy and LDL-C in group F ob- viously decreased, while HDL-C obviously increased, and there was significant difference between two groups （ P 〈0.05）. There was no significant difference in TG and TC between two groups（ P 〉0.05）. There was no significant difference between hyperhomocysteinaemia and cerebral infarction patients with high blood pres- sure, diabetes mellitus and coronary heart disease in group R and group F（ P 〉0.05）. The recurrence rate of cerebral infarction patients accompanying with multiple risk factors was obviously higher than that of cerebral infarction patients without or accompanying with single risk factors. [Conclusion] Besides the conventional risk factors such as high pressure, diabetes mellitus and coronary heart disease, hyperhomocysteinaemia is the main risk factor of the recurrence of cerebra infarction with hyperhomocysteinaemia.
出处
《医学临床研究》
CAS
2013年第2期215-216,219,共3页
Journal of Clinical Research
基金
上海市普陀区卫生系统自主创新科研资助项目（2010-33）
