摘要
背景:纳米载银无机抗菌剂具有抗菌谱广、抗菌能力强等特点,是目前口腔无机抗菌材料研究的热点之一。目的:研究纳米载银无机抗菌材料的抗菌性能及抗菌机制,为基础实验研究和临床应用提供参考信息。方法:研究多种口腔纳米载银无机抗菌材料对常见病原菌如变形链球菌、白色念珠菌以及粘性放线菌等的抗菌性能,其中包括最低杀菌浓度以及抗菌率等,同时进行对比分析。并且研究纳米载银无机抗菌材料的抗菌机制,明确其优点与不足。结果与结论:口腔纳米载银无机抗菌材料具有较广的抗菌谱,对变形链球菌、乳酸杆菌、粘性放线菌、白色念珠菌、牙龈卟啉单胞菌、金黄色葡萄球菌以及大肠埃希菌等均具有较强的抗菌性能,最低杀菌浓度较低,而抗菌率较高。但是同一纳米载银无机抗菌材料对不同的病原菌,其最低杀菌浓度不同,抗菌率也不同,而不同的纳米载银无机抗菌材料对同一病原菌的最低杀菌浓度也不相同,抗菌率也不同。
BACKGROUND： Nano-silver inorganic antimicrobial agent has the characteristics of broad spectrum antimicrobial and antibacterial ability which is one of the hotspots of oral inorganic antibacterial materials research.OBJECTIVE： To study the antibacterial properties and antibacterial mechanism of nano-silver inorganic antimicrobial materials in order to provide reference information for the basic experimental research and the clinical application.METHODS： The antibacterial properties of various oral nano-silver inorganic antimicrobial materials to the common pathogens, such as Streptococcus mutans, Candida a/bicans and Actinomyces viscosus were analyzed, the antibacterial properties included the minimum bactericidal concentration and antibacterial rate, and the comparative analysis of them was performed. The antibacterial mechanism of nano-silver inorganic antimicrobial materials was researched to clear its advantages and disadvantages.RESULTS AND CONCLUSION： The oral nano-silver inorganic antimicrobial materials had a broad antibacterial spectrum, and had strong antibacterial properties to Streptococcus mutans, Lactobacillus, Actinomyces viscosus,Candida albicans, Porphyromonas gingivalis Aeromonas, Staphylococcus aureus and Escherichia coli. It had the lower minimum bactericidal concentration and the higher antibiotic rate. However, the antibacterial properties of the same nano-silver inorganic antibacterial material for different pathogens were different, showing the different minimum bactericidal concentrations and the different antibacterial rates. On the other hand, different nano-silver inorganic antibacterial materials for the same pathogen had different minimum bactericidal concentrations and different antibacterial rates.
出处
《中国组织工程研究》
CAS
CSCD
2013年第3期544-551,共8页
Chinese Journal of Tissue Engineering Research
