摘要
背景:wnt信号通路作为一条多环节、多作用位点的开放通路,在神经系统中扮演着非常重要的角色,因此,了解其具体作用及可能的作用机制,对于神经发生的研究具有非常重要的意义。目的:分析对wnt信号通路在神经发生中的作用及可能机制。方法:以检索词"wnt信号通路"或"神经发生"或"wnt信号通路与神经发生"为检索词,检索2001年1月至2011年12月国内外关于wnt信号通路及其与神经发生相关的文献,选择针对性强、代表性好的19篇文献进行综述,分析wnt信号通路对神经发生的作用与可能机制。结果与结论:无论是在动物的胚胎期、成年期的神经发生,还是在皮质模式发生以及突触形成过程中,均有wnt信号通路的参与。但是wnt信号通路对于神经系统的作用并不总是一致的,神经干细胞自身的特点及所处的微环境会导致细胞对wnt信号的不同反应;不同的wnt信号通路下游靶基因产生的作用也不尽相同;同时,wnt信号通路可能与多种信号途径"crosstalk",通过相互协同,最终表现出对神经系统的特定效应,但其具体的细胞或分子机制仍不甚清楚。
BACKGROUND： As an open, multi-link and multi-site pathway, wnt signaling pathway plays a very important role in the nervous system. Therefore, it is very important to understand the effects and possible mechanisms for neurogenesis research.
OBJECTIVE： To summarize the effect and possible mechanism of wnt signaling pathway in the process of neurogenesis.METHODS： The literatures about the wnt signaling pathway in neurogenesis both at home and abroad were searched, which were published from January 2001 to December 2011, and 19 articles considered to be representative were selected, and then summarized and analyzed.RESULTS AND CONCLUSION： The wnt signaling pathway is involved in embryonic and adult neurogenesis, cortex model and synapse formation. But the role of wnt signaling pathway in these processes is not always consistent. The characteristics and microenvironment of neural stem cells as well as different downstream target genes can cause different effects. Meanwhile, the wnt signaling pathway may interact with a variety of signaling pathways, so the final effect on the nervous system is very specific. However, the clear cellular or molecular mechanisms are still not very sure.
出处
《中国组织工程研究》
CAS
CSCD
2013年第2期358-362,共5页
Chinese Journal of Tissue Engineering Research
关键词
组织构建
组织构建学术探讨
WNT信号通路
神经干细胞
神经发生
作用机制
综述文献
tissue construction
academic discussion in tissue construction
writ signal pathway
neural stem cells
neurogenesis
action mechanism
review literature
