摘要
探讨Th1／Th2细胞失衡在Graves病发病中的作用。方法：应用酶联免疫吸附法分别检测29例新诊断但未治疗的Graves病患者（GD组）和21例正常对照者（NC组）血清IFN-γ、IL-4（分别代表Th1、Th2分泌的细胞因子）水平，并与血清甲状腺过氧化物酶抗体（TPOAb）、甲状腺球蛋白抗体（TGAb）进行相关分析。结果：GD组患者IFN-γ水平与NC组差异无统计学意义（P〉0．05）；GD组患者IL-4水平较NC组高，差异有统计学意义（P〈0．05）；GD患者血清IL-4与TPOAb水平呈显著正相关（r=0．419，P〈0．05），但IL-4与TGAb水平（r=0．357，P〉0．05）及IFN-γ与TPOAb、TGAb水平均无相关性（分别为r=0．180，r=0．222；P〉0．05）。结论：新诊断未治疗的Graves患者以分泌Th2型细胞因子为主，其Th1／Th2细胞免疫失衡偏向Th2细胞占优势的免疫应答。
OBJECTIVE ： To investigate the Th1/Th2 cell imbalance in the pathogenesis of Graves disease. METHODS ： 29 patients with Graves disease （ GD group） and 21 healthy subjects （ control group） were enrolled in the study. All the patients were newly diagnosed and untreated. The serum concentrations of IFN-γ、 IL - 4 （ representative cytokines of Th1 and Th2 cells respectively） were measured by enzymelinked immunosorbent assay. The relations between the level of thyroid peroxidase antibody （TPOAb） and thyroglobulin antibody （TGAb） and the level of IFN -γ and IL -4 were analyzed. RESULTS： There were no significant difference in the IFN -γ level between the GD group and the control group （ P 〉 O. 05 ）. The level of IL - 4 was higher than that of the control group （P 〈 0. 05）. There was positive relation between IL -4 and TPOAb （ r = 0. 419,P 〈 0. 05 ）. But there were no significant correlation among the level of IL-4 and TGAb （ r = 0. 357 ,P 〉0. 05）, the level of IFN -γ and TPOAb and the level of TGAb （ r = 0. 180,r = 0. 222,P 〉 0.05）. CONCLUSION： Th2 cell immune response plays an important role in the pathogenesis of GD.
出处
《国际老年医学杂志》
2013年第2期55-57,共3页
International Journal of Geriatrics
