摘要
目的研究朝鲜苍术挥发油成分,为朝鲜苍术的药用价值及合理开发利用提供参考。方法采用水蒸气蒸馏法提取挥发油,GC毛细管柱色谱法进行分析,峰面积归一化法确定其相对含量,气相色谱-质谱联用技术辅助人工检索鉴定其化学成分。结果从朝鲜苍术的挥发油中分离出58种,鉴定出55种化学成分,鉴定出的挥发性化学成分占挥发油总量的79.94%,主要成分有苍术酮(31.1831%)、3-羟基-6β-环丙烷-5β-胆甾烷(12.3086%)、5α-螺甾烷(11.2161%)、巴伦西亚橘烯(7.05606%)、γ-榄香烯(4.24732%)、菜油甾醇(2.11089%)、石竹烯(1.44473%)、β-桉叶烯(1.43541%)、9,10-脱水-异长叶烯(1.21445%)、α-石竹烯(0.72132%)。结论朝鲜苍术挥发油的主要化学成分为倍半萜类化合物。
Objective To analyze the volatile oil constituent of Atractylodes coreana（Nakai） Kitam. Methods The volatile oil was extracted by steam distillation, analyzed by capillary GC. The relative content of chemical components was calculated by peak area normalization method, the chemical components were identified by gas chromatography mass spectrometry. Results We found that 58 components were isolated, 55 components were identified, the identified chemical components account for 79.94 % of the total volatile oil, including 1,2-Bis-[4-pyridine-N-oxide]ethane （31.1831%）, [5,6]cholestan -3 -ol,3＇,6 -dihydro -, （3.beta.,5.beta.,6.alpha.） -Cyclopropa （12.3086 % ）,Sa -Spirostan （11.2161%）, 1,2,3,5,6,7,8,8a- octahydro- 1,Sa-dimethyl-7- （1 -methylethenyl）-, [1R.- （1 .alpha.,7.beta.,Sa.alpha.）]- Naphthalene（7.05606%）, T-Elemene（4.24732%） , 8（14）-en-3-ol,（3.beta.）-Ergost（2.11089%） ,Caryophyllene（1.44473%）, decahydro -4a-methyl-1 -methylene-7 -（1 -methylethenyl） -, [4aR-（4a.alpha.,7.alpha.,Sa.beta.）] -Naphthalene （1.43541%）,9,10-dehydro-isolonglfolene（1.21445%）,α-CaryophyUene（0.72132%）. Conclusion We concluded that the main chemical components ofAtractylodes coreana（Nakai） kitam. volatile oil are sesquiterpenoids.
出处
《中国药物警戒》
2013年第3期148-151,共4页
Chinese Journal of Pharmacovigilance
关键词
朝鲜苍术
水蒸气蒸馏法
挥发油
气相色谱-质谱法
Atractylodes coreana（Nakai） Kitam
steam distillation
volatile oil
gas chromatography mass spectrometry
