摘要
目的探讨氨氯地平联用小檗碱治疗轻、中度老年高血压合并痛风患者的疗效。方法选择轻、中度老年高血压合并痛风患者164例,按随机数字法分为两组。对照组80例给予口服氨氯地平5 mg、每日2次,同时给予急性痛风患者口服秋水仙碱1 mg、每日3次,慢性痛风患者口服别嘌呤醇50 mg、每日2次。治疗组84例在此基础上加用盐酸小檗碱0.3 g,每日3次。比较两组患者治疗后血尿酸(BUA)、舒张压(DBP)、收缩压(SBP)、总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)及低密度脂蛋白胆固醇(LDL-C)等指标的变化。结果与治疗前比较,两组治疗后BUA,DBP,SBP均有统计学上的显著性意义(P<0.05);治疗后观察组BUA水平改善优于对照组(P<0.05);两组治疗后与治疗前比较,TC,TG,HDL-C,LDL-C均有统计学上的显著性意义(P<0.05),且观察组均优于对照组(P<0.05)。结论氨氯地平联用小檗碱治疗轻、中度老年高血压合并痛风患者,疗效确切、安全可控。
Objective To investigate the effect of amlodipine and berberine in mild and midrange hypertension patients complicated with hyperurieemia arthrolithiasis. Methods We analyzed 164 cases who had mild and midrange hypertension complicated with hyperuricmnia arthrolithiasis. A hundred and sixty- four cases were randomly divided into 2 groups of 80 cases in experimental group who had given oral amlodipine 5 rag/time, 2 times/d, and at the same time give patients with acute arthrolithiasis, oral autumn narcissus alkali 1 rag/time, three times/d, patients with chronic arthrolithiasis, oral don＇t purine ＇alcohol 50 mg/time, 2 times/d, and 84 cases in the control group who had given add with 0.3 g/time in experimental group. Contrast the level of BUA, DBP, SBP, TC, TG, HDL- C, LDL- C. Results There were significant difference BUA, DBP, SBP, TC, TG, HDL-C, LDL-C in prior and post treatment in groups（P 〈 0.05）. There were significant difference BUA, TC, TC, HDL-C, LDL-C in post treatment in groups（P〈 0. 05）. Conclusion Amlodipine and berbcrine in mild and midrange hypertension patients complicated with hyperuricemia arthrolithiasis, can effectively reduce the BUA, DBP and SBP and lipid levels.
出处
《中国药业》
CAS
2013年第5期32-33,共2页
China Pharmaceuticals
关键词
氨氯地平
小檗碱
高血压
痛风
amlodipine
berberine
hypertension
arthrolithiasis
